The selective NOX4 inhibitor GLX7013159 decreases blood glucose concentrations and human beta-cell apoptotic rates in diabetic NMRI nu/nu mice transplanted with human islets.

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey; Carlsson, Per-Ola

Elksnis, Andris; Welsh, Nils; Wikström, Per; Lau, Joey; Carlsson, Per-Ola.

Afiliação

Elksnis A; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Welsh N; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Wikström P; Glucox Biotech AB, Stockholm, Sweden.
Lau J; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.
Carlsson PO; Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

Free Radic Res ; 57(6-12): 460-469, 2023.

Article em En | MEDLINE | ID: mdl-37972305

Assuntos

Diabetes Mellitus Experimental; Insulinas; Humanos; Camundongos; Animais; NADPH Oxidase 4; Glicemia; Hipoglicemiantes; Insulina; Glucose/farmacologia

Palavras-chave

NADPH oxidase; NOX inhibitor; NOX4; beta-cell death; diabetes; human islet; reactive oxygen radical

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Insulinas Limite: Animals / Humans Idioma: En Revista: Free Radic Res Assunto da revista: BIOQUIMICA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Suécia

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