Characterization of the SF3B1-SUGP1 interface reveals how numerous cancer mutations cause mRNA missplicing.

Zhang, Jian; Xie, Jindou; Huang, Ji; Liu, Xiangyang; Xu, Ruihong; Tholen, Jonas; Galej, Wojciech P; Tong, Liang; Manley, James L; Liu, Zhaoqi

Zhang, Jian; Xie, Jindou; Huang, Ji; Liu, Xiangyang; Xu, Ruihong; Tholen, Jonas; Galej, Wojciech P; Tong, Liang; Manley, James L; Liu, Zhaoqi.

Afiliação

Zhang J; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Xie J; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Huang J; University of Chinese Academy of Sciences, Beijing 100049, China.
Liu X; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Xu R; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.
Tholen J; CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences and China National Center for Bioinformation, Beijing 100101, China.
Galej WP; University of Chinese Academy of Sciences, Beijing 100049, China.
Tong L; European Molecular Biology Laboratory, 38042 Grenoble, France.
Manley JL; European Molecular Biology Laboratory, 38042 Grenoble, France.
Liu Z; Department of Biological Sciences, Columbia University, New York, New York 10027, USA.

Genes Dev ; 37(21-24): 968-983, 2023 Dec 26.

Article em En | MEDLINE | ID: mdl-37977822

Assuntos

Neoplasias; Spliceossomos; Humanos; RNA Mensageiro/metabolismo; Spliceossomos/genética; Spliceossomos/metabolismo; Fatores de Processamento de RNA/química; Splicing de RNA/genética; Neoplasias/genética; Neoplasias/metabolismo; Mutação; Fosfoproteínas/metabolismo

Palavras-chave

AlphaFold-Multimer; DHX15; G-patch; myelodysplastic syndromes; spliceosome mutations

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Spliceossomos / Neoplasias Limite: Humans Idioma: En Revista: Genes Dev Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos

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