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Molecular characterization and whole-genome sequencing of Corynebacterium diphtheriae causing skin lesion.
Ramos, Juliana Nunes; Araújo, Max Roberto Batista; Sant'Anna, Lincoln Oliveira; Bokermann, Sérgio; Camargo, Carlos Henrique; Prates, Fernanda Diniz; Sacchi, Cláudio Tavares; Vieira, Verônica Viana; Campos, Karoline Rodrigues; Santos, Marlon Benedito Nascimento; Viana, Marcus Vinícius Canário; Azevedo, Vasco; Aburjaile, Flávia Figueira; de Mattos-Guaraldi, Ana Luiza; Dos Santos, Louisy Sanches.
Afiliação
  • Ramos JN; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Araújo MRB; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute, Belo Horizonte, Minas Gerais, Brazil.
  • Sant'Anna LO; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Bokermann S; Center of Bacteriology, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, São Paulo, Brazil.
  • Camargo CH; Center of Bacteriology, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, São Paulo, Brazil.
  • Prates FD; Operational Technical Nucleus, Microbiology, Hermes Pardini Institute, Belo Horizonte, Minas Gerais, Brazil.
  • Sacchi CT; Strategic Laboratory, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, São Paulo, Brazil.
  • Vieira VV; Interdisciplinary Laboratory of Medical Research, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil.
  • Campos KR; Strategic Laboratory, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, São Paulo, Brazil.
  • Santos MBN; Strategic Laboratory, Adolfo Lutz Institute, Secretary of Health of the State of São Paulo, São Paulo, Brazil.
  • Viana MVC; Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Azevedo V; Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Aburjaile FF; Department of Preventive Veterinary Medicine, Veterinary School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • de Mattos-Guaraldi AL; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
  • Dos Santos LS; Laboratory of Diphtheria and Corynebacteria of Clinical Relevance, Department of Microbiology, Immunology and Parasitology, Rio de Janeiro State University, Rio de Janeiro, Brazil. louisysanchesuerj@gmail.com.
Eur J Clin Microbiol Infect Dis ; 43(1): 203-208, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37985550
ABSTRACT
We present a case of skin lesion caused by nontoxigenic Corynebacterium diphtheriae. Genomic taxonomy analyses corroborated the preliminary identification provided by mass spectrometry. The strain showed a susceptible phenotype with increased exposure to penicillin, the first drug of choice for the treatment. An empty type 1 class integron carrying only the sul1 gene, which encodes sulfonamide resistance, was found flanked by transposases. Virulence factors involved in adherence and iron uptake, as well as the CRISPR-Cas system, were predicted. MLST analysis revealed the ST-681, previously reported in French Guiana, a European territory.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corynebacterium diphtheriae Limite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Corynebacterium diphtheriae Limite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Brasil