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The Possible Role of Brain-derived Neurotrophic Factor in Epilepsy.
AlRuwaili, Raed; Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Ali, Naif H; Alexiou, Athanasios; Papadakis, Marios; Saad, Hebatallah M; Batiha, Gaber El-Saber.
Afiliação
  • AlRuwaili R; Department of Internal Medicine, College of Medicine, Jouf University, Sakaka, Saudi Arabia.
  • Al-Kuraishy HM; Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, P.O. Box 14132, Baghdad, Iraq.
  • Al-Gareeb AI; Department of Clinical Pharmacology and Medicine, College of Medicine, ALmustansiriyia University, P.O. Box 14132, Baghdad, Iraq.
  • Ali NH; Department of Internal Medicine, Medical College, Najran University, Najran, Saudi Arabia.
  • Alexiou A; University Centre for Research & Development, Chandigarh University, Chandigarh-Ludhiana Highway, Mohali, Punjab, India.
  • Papadakis M; Department of Research & Development, Funogen, Athens, Greece.
  • Saad HM; Department of Research & Development, AFNP Med, Wien, 1030, Austria.
  • Batiha GE; Department of Science and Engineering, Novel Global Community Educational Foundation, Hebersham, NSW, 2770, Australia.
Neurochem Res ; 49(3): 533-547, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38006577
Epilepsy is a neurological disease characterized by repeated seizures. Despite of that the brain-derived neurotrophic factor (BDNF) is implicated in the pathogenesis of epileptogenesis and epilepsy, BDNF may have a neuroprotective effect against epilepsy. Thus, the goal of the present review was to highlight the protective and detrimental roles of BDNF in epilepsy. In this review, we also try to find the relation of BDNF with other signaling pathways and cellular processes including autophagy, mTOR pathway, progranulin (PGN), and α-Synuclein (α-Syn) which negatively and positively regulate BDNF/tyrosine kinase receptor B (TrkB) signaling pathway. Therefore, the assessment of BDNF levels in epilepsy should be related to other neuronal signaling pathways and types of epilepsy in both preclinical and clinical studies. In conclusion, there is a strong controversy concerning the potential role of BDNF in epilepsy. Therefore, preclinical, molecular, and clinical studies are warranted in this regard.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Epilepsia Limite: Humans Idioma: En Revista: Neurochem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Arábia Saudita

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fator Neurotrófico Derivado do Encéfalo / Epilepsia Limite: Humans Idioma: En Revista: Neurochem Res Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Arábia Saudita