TFE-Facilitated Synthesis of Tetrahydropyridino[2,3-d]pyrimidine via Cascade [1,5]-Hydride Transfer/Cyclization.
J Org Chem
; 88(24): 17144-17154, 2023 Dec 15.
Article
em En
| MEDLINE
| ID: mdl-38010354
ABSTRACT
An efficient fluorinated alcohol-driven cascade [1,5]-hydride transfer/cyclization between o-amino pyridyl aldehydes and primary amines has been developed. This unique transformation enabled an array of tetrahydropyridino[2,3-d]pyrimidine construction. Furthermore, the encouraging antifungal activity of Thanatephorus cucumeris was demonstrated by this tetrahydropyridino[2,3-d]pyrimidine core structure.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Ano de publicação:
2023
Tipo de documento:
Article