Inhibitory effects of ursolic and oleanolic acid on skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate.
Cancer Lett
; 33(3): 279-85, 1986 Dec.
Article
em En
| MEDLINE
| ID: mdl-3802058
ABSTRACT
Ursolic acid (UA) and oleanolic acid (OA), which had been isolated from Glechoma hederacea as inhibitors of Epstein-Barr virus (EBV) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), were tested against inhibitory effect on tumor promotion by TPA in vivo. They inhibited effectively the tumor promotion in mouse skin and the activities were comparable to that of a known inhibitor of tumor promotion, retinoic acid (RA). Interestingly, UA was more effective on a single application before initial TPA-treatment than on a continuous application before each TPA-treatment, while OA and RA were ineffective in the same treatment. These data suggest that the role of UA for inhibitory action on tumor promotion differs slightly from those of RA and OA.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ácido Oleanólico
/
Sapogeninas
/
Neoplasias Cutâneas
/
Triterpenos
/
Antineoplásicos Fitogênicos
Limite:
Animals
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
1986
Tipo de documento:
Article