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Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa.
Zhou, Weiyin; Fischer, Anja; Ogwang, Martin D; Luo, Wen; Kerchan, Patrick; Reynolds, Steven J; Tenge, Constance N; Were, Pamela A; Kuremu, Robert T; Wekesa, Walter N; Masalu, Nestory; Kawira, Esther; Kinyera, Tobias; Otim, Isaac; Legason, Ismail D; Nabalende, Hadijah; Ayers, Leona W; Bhatia, Kishor; Goedert, James J; Gouveia, Mateus H; Cole, Nathan; Hicks, Belynda; Jones, Kristine; Hummel, Michael; Schlesner, Mathias; Chagaluka, George; Mutalima, Nora; Borgstein, Eric; Liomba, George N; Kamiza, Steve; Mkandawire, Nyengo; Mitambo, Collins; Molyneux, Elizabeth M; Newton, Robert; Glaser, Selina; Kretzmer, Helene; Manning, Michelle; Hutchinson, Amy; Hsing, Ann W; Tettey, Yao; Adjei, Andrew A; Chanock, Stephen J; Siebert, Reiner; Yeager, Meredith; Prokunina-Olsson, Ludmila; Machiela, Mitchell J; Mbulaiteye, Sam M.
Afiliação
  • Zhou W; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Fischer A; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Ogwang MD; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
  • Luo W; EMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Kerchan P; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Reynolds SJ; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Tenge CN; EMBLEM Study, Kuluva Hospital, Arua, Uganda.
  • Were PA; Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
  • Kuremu RT; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
  • Wekesa WN; EMBLEM Study, Academic Model Providing Access To Healthcare (AMPATH), Eldoret, Kenya.
  • Masalu N; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
  • Kawira E; EMBLEM Study, Moi University College of Health Sciences, Eldoret, Kenya.
  • Kinyera T; EMBLEM Study, Bugando Medical Center, Mwanza, Tanzania.
  • Otim I; EMBLEM Study, Shirati Health, Education, and Development Foundation, Shirati, Tanzania.
  • Legason ID; EMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Nabalende H; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Ayers LW; EMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Bhatia K; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Goedert JJ; EMBLEM Study, Kuluva Hospital, Arua, Uganda.
  • Gouveia MH; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Cole N; EMBLEM Study, St. Mary's Hospital, Lacor, Gulu, Uganda.
  • Hicks B; EMBLEM Study, African Field Epidemiology Network, Kampala, Uganda.
  • Jones K; Department of Pathology, The Ohio State University, Columbus, OH, USA.
  • Hummel M; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Schlesner M; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Chagaluka G; Center for Research on Genomics & Global Health, NHGRI, National Institutes of Health, Bethesda, MD, USA.
  • Mutalima N; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Borgstein E; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Liomba GN; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Kamiza S; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Mkandawire N; Division of Cancer Epidemiology & Genetics, National Cancer Institute, National Institutes of Health, US Department of Health and Human Services, Bethesda, MD, USA.
  • Mitambo C; Cancer Genomics Research Laboratory, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
  • Molyneux EM; Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Berlin, Germany.
  • Newton R; Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Pathology, D-10117, Berlin, Germany.
  • Glaser S; Biomedical Informatics, Data Mining and Data Analytics, University of Augsburg, Augsburg, Germany.
  • Kretzmer H; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Manning M; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
  • Hutchinson A; Cancer Epidemiology Unit, University of Oxford, Oxford, UK.
  • Hsing AW; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Tettey Y; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Adjei AA; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Chanock SJ; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Siebert R; Research Department, Ministry of Health, P.O. Box 30377, Lilongwe 3, Malawi.
  • Yeager M; Departments of Pediatrics and Surgery, College of Medicine, University of Malawi, Blantyre, Malawi.
  • Prokunina-Olsson L; Epidemiology and Cancer Statistics Group, Department of Health Sciences, University of York, York, UK.
  • Machiela MJ; Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.
  • Mbulaiteye SM; Department of Genome Regulation, Max Planck Institute for Molecular Genetics, Berlin, Germany.
Nat Commun ; 14(1): 8081, 2023 Dec 06.
Article em En | MEDLINE | ID: mdl-38057307
In high-income countries, mosaic chromosomal alterations in peripheral blood leukocytes are associated with an elevated risk of adverse health outcomes, including hematologic malignancies. We investigate mosaic chromosomal alterations in sub-Saharan Africa among 931 children with Burkitt lymphoma, an aggressive lymphoma commonly characterized by immunoglobulin-MYC chromosomal rearrangements, 3822 Burkitt lymphoma-free children, and 674 cancer-free men from Ghana. We find autosomal and X chromosome mosaic chromosomal alterations in 3.4% and 1.7% of Burkitt lymphoma-free children, and 8.4% and 3.7% of children with Burkitt lymphoma (P-values = 5.7×10-11 and 3.74×10-2, respectively). Autosomal mosaic chromosomal alterations are detected in 14.0% of Ghanaian men and increase with age. Mosaic chromosomal alterations in Burkitt lymphoma cases include gains on chromosomes 1q and 8, the latter spanning MYC, while mosaic chromosomal alterations in Burkitt lymphoma-free children include copy-neutral loss of heterozygosity on chromosomes 10, 14, and 16. Our results highlight mosaic chromosomal alterations in sub-Saharan African populations as a promising area of research.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma de Burkitt Limite: Child / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
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Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfoma de Burkitt Limite: Child / Humans / Male País/Região como assunto: Africa Idioma: En Revista: Nat Commun Assunto da revista: BIOLOGIA / CIENCIA Ano de publicação: 2023 Tipo de documento: Article País de afiliação: Estados Unidos