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Pyoderma Gangrenosum in a Young Nigerian Male with Severe Ulcerative Colitis: A Case Report.
Onyia, C P; Asogwa, P; Adiri, W; Obienu, O; Ijoma, U N; Nwokediuko, S C.
Afiliação
  • Onyia CP; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. Email: chyphilomina@gmail.com, Cell: +2348033922971.
  • Asogwa P; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. Email: chyphilomina@gmail.com, Cell: +2348033922971.
  • Adiri W; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. Email: chyphilomina@gmail.com, Cell: +2348033922971.
  • Obienu O; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. Email: chyphilomina@gmail.com, Cell: +2348033922971.
  • Ijoma UN; Gastroenterology Unit, Department of Medicine, University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Nigeria. Email: chyphilomina@gmail.com, Cell: +2348033922971.
  • Nwokediuko SC; Department of Medicine, Faculty of Medical Sciences, College of Medicine, University of Nigeria, Ituku-Ozalla Campus, Enugu, Nigeria.
West Afr J Med ; 40(11): 1274-1279, 2023 11 30.
Article em En | MEDLINE | ID: mdl-38099570
ABSTRACT
Pyoderma gangrenosum manifests as recurrent deep ulceration of the skin and is associated with a variety of disorders. We report a 40-year-old man who developed ulcers on the flexor surface of his right lower limb following a trauma 10 years prior to the current presentation. He was diagnosed with ulcerative colitis 20 years ago, and was previously placed on sulfasalazine and prednisolone. He also developed an enterocutaneous fistula at the right iliac fossa following an appendectomy he had 16 years previously. Mayo score of his ulcerative colitis was severe (11/12), and he received three courses of intravenous infliximab at irregular intervals as it was difficult to access Infliximab in Nigeria. He was stepped down to tablet Mesalazine after the third course due to cost considerations, and skin grafting was done for the extensive leg ulcer to achieve wound healing after failed steroid and sulfasalazine therapy.
Le pyoderma gangrenosum se manifeste par des ulcères profonds récurrents de la peau et est associé à divers troubles. Nous rapportons le cas d'un homme de 40 ans qui a développé des ulcères sur la face antérieure de sa jambe droite suite à un traumatisme survenu 10 ans avant la présentation actuelle. Il a été diagnostiqué d'une rectocolite hémorragique il y a 20 ans et avait précédemment été traité par sulfasalazine et prednisolone. Il a également développé une fistule entérocutanée à la fosse iliaque droite suite à une appendicectomie subie 16 ans auparavant. Le score de Mayo de sa rectocolite hémorragique était sévère (11/12), et il a reçu trois cures d'infliximab par voie intraveineuse à des intervalles irréguliers en raison de la difficulté d'accès à l'infliximab au Nigeria. Il est passé à la mésalazine en comprimés après la troisième cure en raison de considérations budgétaires, et une greffe de peau a été réalisée pour l'ulcère étendu de la jambe afin d'obtenir une cicatrisation après l'échec du traitement par stéroïdes et sulfasalazine. Mots-clés pyoderma gangrenosum, Rectocolite hémorragique, Infliximab, Africain, Ulcères aphteux.
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Pioderma Gangrenoso Limite: Adult / Humans / Male Idioma: En Revista: West Afr J Med Ano de publicação: 2023 Tipo de documento: Article
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Colite Ulcerativa / Pioderma Gangrenoso Limite: Adult / Humans / Male Idioma: En Revista: West Afr J Med Ano de publicação: 2023 Tipo de documento: Article