Advancement in structure elucidation of natural medium-sized lactones through synthesis and theoretical calculations.
Biosci Biotechnol Biochem
; 88(3): 260-269, 2024 Feb 21.
Article
em En
| MEDLINE
| ID: mdl-38111271
ABSTRACT
Medium-sized lactones are an important class of natural products with diverse biological activities. Unlike conventional organic compounds, these molecules exhibit elevated levels of conformational flexibility. This inherent structural feature occasionally exacerbates the complexities associated with determining their conformation, thereby posing challenges in deciphering their stereochemistry or, in certain instances, leading to incorrect structures. This review highlights specific scenarios in which synthetic studies and computational chemistry have assumed pivotal roles in unveiling the structures of lactones, which have previously eluded definitive elucidation.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Lactonas
Idioma:
En
Revista:
Biosci Biotechnol Biochem
Assunto da revista:
BIOQUIMICA
/
BIOTECNOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão