Mouse Models to Evaluate the Functional Role of the Tumor Microenvironment in Cancer Progression and Therapy Responses.
Cold Spring Harb Perspect Med
; 14(7)2024 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-38191175
ABSTRACT
The tumor microenvironment (TME) is a complex ecosystem of both cellular and noncellular components that functions to impact the evolution of cancer. Various aspects of the TME have been targeted for the control of cancer; however, TME composition is dynamic, with the overall abundance of immune cells, endothelial cells (ECs), fibroblasts, and extracellular matrix (ECM) as well as subsets of TME components changing at different stages of progression and in response to therapy. To effectively treat cancer, an understanding of the functional role of the TME is needed. Genetically engineered mouse models have enabled comprehensive insight into the complex interactions within the TME ecosystem that regulate disease progression. Here, we review recent advances in mouse models that have been employed to understand how the TME regulates cancer initiation, progression, metastasis, and response to therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Progressão da Doença
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Modelos Animais de Doenças
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Microambiente Tumoral
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Neoplasias
Limite:
Animals
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Humans
Idioma:
En
Revista:
Cold Spring Harb Perspect Med
/
Cold Spring Harbor perspect. med
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Cold Spring Harbor perspectives in medicine
Ano de publicação:
2024
Tipo de documento:
Article