Noncoding mutations drive persistence of a founder preleukemic clone which initiates late relapse in T-ALL.

O'Connor, David; Valle-Inclán, Jose Espejo; Conde, Lucia; Bloye, Gianna; Rahman, Sunniyat; Costa, Joana R; Bartram, Jack; Adams, Stuart; Wright, Gary; Elrick, Hillary; Wall, Kerry; Dyer, Sara; Howell, Christopher; Jigoulina, Galina; Herrero, Javier; Cortes-Ciriano, Isidro; Moorman, Anthony V; Mansour, Marc R

O'Connor, David; Valle-Inclán, Jose Espejo; Conde, Lucia; Bloye, Gianna; Rahman, Sunniyat; Costa, Joana R; Bartram, Jack; Adams, Stuart; Wright, Gary; Elrick, Hillary; Wall, Kerry; Dyer, Sara; Howell, Christopher; Jigoulina, Galina; Herrero, Javier; Cortes-Ciriano, Isidro; Moorman, Anthony V; Mansour, Marc R.

Afiliação

O'Connor D; UCL Cancer Institute, University College London, London, United Kingdom.
Valle-Inclán JE; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Conde L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Bloye G; UCL Cancer Institute, University College London, London, United Kingdom.
Rahman S; UCL Cancer Institute, University College London, London, United Kingdom.
Costa JR; UCL Cancer Institute, University College London, London, United Kingdom.
Bartram J; Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.
Adams S; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia.
Wright G; UCL Cancer Institute, University College London, London, United Kingdom.
Elrick H; Department of Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Wall K; Specialist Integrated Haematology and Malignancy Diagnostic Service-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Dyer S; Specialist Integrated Haematology and Malignancy Diagnostic Service-Haematology, Great Ormond Street Hospital for Children, London, United Kingdom.
Howell C; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
Jigoulina G; West Midlands Regional Genetics Laboratory, Birmingham, United Kingdom.
Herrero J; West Midlands Regional Genetics Laboratory, Birmingham, United Kingdom.
Cortes-Ciriano I; Alder Hey Children's Hospital, Liverpool, United Kingdom.
Moorman AV; Southampton Children's Hospital, Southampton, United Kingdom.
Mansour MR; UCL Cancer Institute, University College London, London, United Kingdom.

Blood ; 143(10): 933-937, 2024 03 07.

Article em En | MEDLINE | ID: mdl-38194681

ABSTRACT

ABSTRACT

ABSTRACT T-ALL relapse usually occurs early but can occur much later, which has been suggested to represent a de novo leukemia. However, we conclusively demonstrate late relapse can evolve from a pre-leukemic subclone harbouring a non-coding mutation that evades initial chemotherapy.

Assuntos

Leucemia-Linfoma de Células T do Adulto; Leucemia-Linfoma Linfoblástico de Células T Precursoras; Humanos; Leucemia-Linfoma Linfoblástico de Células T Precursoras/genética; Mutação; Recidiva; Doença Crônica; Células Clonais

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma de Células T do Adulto / Leucemia-Linfoma Linfoblástico de Células T Precursoras Limite: Humans Idioma: En Revista: Blood Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Reino Unido

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