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Clinical outcomes and complications of S53P4 bioactive glass in chronic osteomyelitis and septic non-unions: a retrospective single-center study.
Gatti, Simone Daniel; Gaddi, Diego; Turati, Marco; Leone, Giulio; Arts, Jacobus J; Pessina, Fabio; Carminati, Mattia; Zatti, Giovanni; De Rosa, Laura; Bigoni, Marco.
Afiliação
  • Gatti SD; School of Medicine and Surgery, University of Milano, Bicocca, Monza, Italy.
  • Gaddi D; Department of Orthopedic Surgery, Policlinico San Pietro, Ponte San Pietro, Italy.
  • Turati M; School of Medicine and Surgery, University of Milano, Bicocca, Monza, Italy. marco.turati@unimib.it.
  • Leone G; Orthopedic Department, IRCCS San Gerardo dei Tintori, Via Pergolesi, 33, 20900, Monza, Italy. marco.turati@unimib.it.
  • Arts JJ; Transalpine Center of Pediatric Sports Medicine and Surgery, University of Milano-Bicocca - Hospital Couple Enfant, Monza (Italy), Grenoble, France. marco.turati@unimib.it.
  • Pessina F; Department of Paediatric Orthopedic Surgery, Hospital Couple Enfants, Grenoble Alpes University, Grenoble, France. marco.turati@unimib.it.
  • Carminati M; Orthopedic Department, IRCCS San Gerardo dei Tintori, Via Pergolesi, 33, 20900, Monza, Italy.
  • Zatti G; Department Orthopaedic Biomechanics, Faculty Biomedical Engineering, Eindhoven University of Technology TU/e, Eindhoven, Netherlands.
  • De Rosa L; Department Orthopaedic Surgery, Maastricht University Medical Centre, Maastricht, the Netherlands.
  • Bigoni M; School of Medicine and Surgery, University of Milano, Bicocca, Monza, Italy.
Eur J Clin Microbiol Infect Dis ; 43(3): 489-499, 2024 Mar.
Article em En | MEDLINE | ID: mdl-38195783
ABSTRACT

INTRODUCTION:

Dead space management following debridement surgery in chronic osteomyelitis or septic non-unions is one of the most crucial and discussed steps for the success of the surgical treatment of these conditions. In this retrospective clinical study, we described the efficacy and safety profile of surgical debridement and local application of S53P4 bioactive glass (S53P4 BAG) in the treatment of bone infections.

METHODS:

A consecutive single-center series of 38 patients with chronic osteomyelitis (24) and septic non-unions (14), treated with bioactive glass S53P4 as dead space management following surgical debridement between May 2015 and November 2020, were identified and evaluated retrospectively.

RESULTS:

Infection eradication was reached in 22 out of 24 patients (91.7%) with chronic osteomyelitis. Eleven out of 14 patients (78.6%) with septic non-union achieved both fracture healing and infection healing in 9.1 ± 4.9 months. Three patients (7.9%) developed prolonged serous discharge with wound dehiscence but healed within 2 months with no further surgical intervention. Average patient follow-up time was 19.8 months ± 7.6 months.

CONCLUSION:

S53P4 bioactive glass is an effective and safe therapeutic option in the treatment of chronic osteomyelitis and septic non-unions because of its unique antibacterial properties, but also for its ability to generate a growth response in the remaining healthy bone at the bone-glass interface.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Substitutos Ósseos Limite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Osteomielite / Substitutos Ósseos Limite: Humans Idioma: En Revista: Eur J Clin Microbiol Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS / MICROBIOLOGIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Itália