Loss in life expectancy in patients with stage II-III cutaneous melanoma in Sweden: A population-based cohort study.
J Am Acad Dermatol
; 90(5): 963-969, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38218560
ABSTRACT
BACKGROUND:
Survival in cutaneous melanoma (CM) is heterogeneous. Loss in life expectancy (LLE) measures impact of CM on remaining lifespan compared to general population.OBJECTIVES:
Investigating LLE in operated stage II-III CM patients.METHODS:
Data from 8061 patients (aged 40-80 years) with stage II-III CM in Sweden, diagnosed between 2005 and 2018, were analyzed (Swedish Melanoma Registry). A flexible parametric survival model estimated life expectancy and LLE.RESULTS:
Based on 2018 diagnoses, stage II and III CM patients lost 2209 and 1902 life years, respectively. LLE was higher in stage III 5.2 versus 10.9 years (stage II vs III 60-year-old females). Younger patients had higher LLE 10.7 versus 3.9 years (stage II CM in 40 vs 70-year-old males). In stage II, females had lower LLE than males; 50-year-old females and males stage II CM had LLE equal to 7.3 and 8.3 years, respectively. LLE increased with higher substages, stage IIB resembling IIIB and IIC resembling IIIC-D.LIMITATIONS:
Extrapolation was used to estimate LLE. Varying stage group sizes require caution.CONCLUSIONS:
Our results are both clinically relevant and easy-to-interpret measures of the impact of CM on survival, but the results also summarize the prognosis over the lifetime of a CM patient.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Cutâneas
/
Melanoma
Tipo de estudo:
Etiology_studies
/
Observational_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
J Am Acad Dermatol
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Suécia