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Transcriptionally Active Defective HIV-1 Proviruses and Their Association With Immunological Nonresponse to Antiretroviral Therapy.
Scrimieri, Francesca; Bastian, Estella; Smith, Mindy; Rehm, Catherine A; Morse, Caryn; Kuruppu, Janaki; McLaughlin, Mary; Chang, Weizhong; Sereti, Irini; Kovacs, Joseph A; Lane, H Clifford; Imamichi, Hiromi.
Afiliação
  • Scrimieri F; Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Bastian E; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Smith M; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Rehm CA; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Morse C; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Kuruppu J; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • McLaughlin M; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Chang W; Applied and Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
  • Sereti I; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Kovacs JA; Critical Care Medicine Department, National Institutes of Health Clinical Center, Bethesda, Maryland, USA.
  • Lane HC; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
  • Imamichi H; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
J Infect Dis ; 229(6): 1786-1790, 2024 Jun 14.
Article em En | MEDLINE | ID: mdl-38226493
ABSTRACT
A subset of antiretroviral therapy-treated persons with human immunodeficiency virus (HIV), referred to as immunological nonresponders (INRs), fails to normalize CD4+ T-cell numbers. In a case-control study involving 26 INRs (CD4 < 250 cells/µL) and 25 immunological responders (IRs; CD4 ≥ 250 cells/µL), we evaluated the potential contribution of transcriptionally competent defective HIV-1 proviruses to poor CD4+ T-cell recovery. Compared to the responders, the INRs had higher levels of cell-associated HIV RNA (P = .034) and higher percentages of HLA-DR+ CD4+ T cells (P < .001). While not encoding replication-competent viruses, the RNA transcripts frequently encoded HIV-1 Gag-p17 and Nef proteins. These transcripts and/or resulting proteins may activate pathway(s) leading to the immunological nonresponse phenotype.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Provírus Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T CD4-Positivos / Infecções por HIV / HIV-1 / Provírus Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: J Infect Dis Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos