Revisiting sensitivity of senescent cells to BH3 mimetics.

Martin, Nadine; Huna, Anda; Tsalikis, Athanasios; Bernard, David

Martin, Nadine; Huna, Anda; Tsalikis, Athanasios; Bernard, David.

Afiliação

Martin N; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France; Equipe Labellisée la Ligue Contre le Cancer, Lyon, France. Electronic address: nadine.martin@lyon.unicancer.fr.
Huna A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France; Equipe Labellisée la Ligue Contre le Cancer, Lyon, France.
Tsalikis A; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France; Equipe Labellisée la Ligue Contre le Cancer, Lyon, France.
Bernard D; Centre de Recherche en Cancérologie de Lyon, Inserm U1052, CNRS UMR 5286, Université de Lyon, Centre Léon Bérard, Lyon, France; Equipe Labellisée la Ligue Contre le Cancer, Lyon, France. Electronic address: david.bernard@lyon.unicancer.fr.

Trends Pharmacol Sci ; 45(4): 287-289, 2024 Apr.

Article em En | MEDLINE | ID: mdl-38245492

ABSTRACT

ABSTRACT

B cell leukemia/lymphoma 2 (BCL2) homology domain 3 (BH3) mimetics were reported to selectively kill senescent cells and improve age-related diseases. Defining why these cells show increased sensitivity to these molecules will help to identify new pharmacological compounds with senolytic activity. Here, we discuss how recent research findings provide new clues to understand this vulnerability.

Assuntos

Senescência Celular; Humanos

Palavras-chave

BCL2; MOMP; aging; cellular senescence; senolytics

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Senescência Celular Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Humans Idioma: En Revista: Trends Pharmacol Sci Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google