Prinzmetal's angina during 5-fluorouracil chemotherapy.
Am J Med
; 82(3): 566-8, 1987 Mar.
Article
em En
| MEDLINE
| ID: mdl-3826112
ABSTRACT
Variant angina developed during intravenous 5-fluorouracil therapy in a patient without prior history of angina pectoris. Ambulatory electrocardiography demonstrated S-T segment elevation and ventricular ectopy during pain, whereas no symptoms or S-T segment changes occurred during placebo therapy. Prophylaxis with both nifedipine and diltiazem was successful in preventing recurrence. It is believed that 5-fluorouracil induced coronary vasospasm and that this was prevented by prophylactic calcium antagonist therapy. Drug-induced coronary artery spasm may be the cause of 5-fluorouracil-associated chest pain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fluoruracila
/
Angina Pectoris Variante
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
Limite:
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Am J Med
Ano de publicação:
1987
Tipo de documento:
Article