Associations of cumulative depressive symptoms within 1-year of discharge with subsequent mortality among patients hospitalized for acute heart failure: Findings from The China PEACE Prospective Heart Failure Study.
J Affect Disord
; 351: 299-308, 2024 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-38290578
ABSTRACT
BACKGROUND:
To examine the associations between cumulative depressive symptoms and subsequent mortality among patients hospitalized for acute hear failure (AHF).METHODS:
By using data from a prospective cohort study of patients with HF, depressive symptoms were measured by using Patient Health Questionnaire-2 (PHQ-2) at admission, 1-and 12-month after discharge. Cumulative depressive symptoms were interpreted by cumulative PHQ-2 score and cumulative times of depressive symptoms. Outcomes included subsequent 3-year all-cause and cardiovascular mortality.RESULTS:
We included 2347 patients with the median follow-up of 4.4 (interquartile range [IQR] 4.0-5.0) years. Tertile 3 of cumulative PHQ-2 score had the highest risk of all-cause (hazard ratio [HR] 1.47, 95 % confidence interval [CI] 1.21-1.78) and cardiovascular mortality (HR 1.51, 95 % CI 1.21-1.89) compared with Tertile 1; patients with≥2 times of depressive symptoms had the highest risk of all-cause (HR 1.62, 95 % CI 1.31-2.00) and cardiovascular mortality (HR 1.60, 95 % CI 1.25-2.05) compared with patients without any depressive symptom. Cumulative PHQ-2 score provided the highest level of incremental prognostic ability in predicting the risk of all-cause (C-statistics 0.64, 95 % CI 0.62-0.66) and cardiovascular mortality (C-statistics 0.65, 95 % CI 0.62-0.67) on the basis of Get With The Guidelines-Heart Failure score.CONCLUSION:
Cumulative depressive symptoms were associated with the increased risk of subsequent mortality and provided incremental prognostic ability for the outcomes among patients with HF. Repeated depressive symptom measurements could be helpful to monitor long-term depressive symptoms, identify targeted patients and perform psychological interventions and social support to improve clinical outcomes among patients with AHF.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alta do Paciente
/
Insuficiência Cardíaca
Tipo de estudo:
Diagnostic_studies
/
Guideline
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Revista:
J Affect Disord
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
China