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Association between green tea intake and digestive system cancer risk in European and East Asian populations: a Mendelian randomization study.
Nie, Duorui; He, Xiaoyu; Zheng, Hao; Deng, Deyu; He, Fanghui; Li, Ruyi; Ni, Xiaoting; Li, Shunxiang; Xu, Fei.
Afiliação
  • Nie D; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • He X; Department of Hematology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
  • Zheng H; First Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • Deng D; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • He F; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • Li R; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • Ni X; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
  • Li S; College of Pharmacy, Hunan University of Chinese Medicine, Changsha, China. lishunxiang@hotmail.com.
  • Xu F; Hunan Engineering Technology Research Center for Bioactive Substance Discovery of Chinese Medicine, Changsha, China. lishunxiang@hotmail.com.
Eur J Nutr ; 63(4): 1103-1111, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38319384
ABSTRACT

PURPOSE:

Previous observational studies have shown that green tea consumption is associated with a reduced incidence of digestive system cancers (DSCs). However, the observed association could be due to confounding factors. Therefore, we used a two-sample Mendelian randomization (MR) approach to assess the causal effect of green tea intake on the risk of five common DSCs.

METHODS:

Independent genetic variants strongly associated with green tea consumption in European and East Asian populations were selected as instrumental variables in genome-wide association studies involving up to 64,949 European individuals and 152,653 East Asian individuals, respectively. The associations between genetic variants and DSCs were extracted from the FinnGen study and the Japan Biobank. The primary analysis was performed using random-effects inverse variance weighting (IVW). Other MR analyses, including weighted mode-based estimate, weighted-median, MR-Egger regression, Mendelian Randomization-Pleiotropy Residual Sum and Outlier (MR-PRESSO) analysis, were used for sensitivity analyses. In addition, a multivariate MR design was performed to adjust for smoking and alcohol consumption.

RESULTS:

The IVW results showed no causal relationship between tea intake and DSCs risk in European population (esophagus cancer odds ratio (OR) = 1.044, 95% confidence interval (CI) 0.992-1.099, p = 0.096; stomach cancer OR = 0.988, 95% CI 0.963-1.014, p = 0.368; colorectal cancer OR = 1.003, 95% CI 0.992-1.015, p = 0.588; liver cancer OR = 0.996, 95% CI 0.960-1.032, p = 0.808; pancreatic cancer OR = 0.990, 95% CI 0.965-1.015, p = 0.432). The MR-Egger regression, MR-PRESSO analysis and other methods also confirmed the reliability of the conclusion. Similarly, no significant association was found between green tea consumption and the incidence of DSCs among East Asians. This relationship is not significant even after adjusting for smoking and alcohol consumption (P > 0.05).

CONCLUSION:

Our study provides evidence that genetically predicted green tea intake is not causally associated with the development of DSCs in the European and East Asian population.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chá / População Branca / Neoplasias do Sistema Digestório / Estudo de Associação Genômica Ampla / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia / Europa Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Chá / População Branca / Neoplasias do Sistema Digestório / Estudo de Associação Genômica Ampla / Análise da Randomização Mendeliana Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans País/Região como assunto: Asia / Europa Idioma: En Revista: Eur J Nutr Assunto da revista: CIENCIAS DA NUTRICAO Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China