Clinical features and prognosis of malignant small bowel tumors: Experience from a university hospital in Chile.
Gastroenterol Hepatol
; 47(5): 491-499, 2024 May.
Article
em En, Es
| MEDLINE
| ID: mdl-38331316
ABSTRACT
BACKGROUND:
Small bowel tumors (SBT) are infrequent and represent a small proportion of digestive neoplasms. There is scarce information about SBT in Latin America.AIM:
To describe the epidemiology, clinical characteristics, diagnostic methods, and survival of malignant SBTs.METHODS:
Retrospective observational study of adult patients with histopathological diagnosis of SBT between 2007 and 2021 in a university hospital in Chile.RESULTS:
A total of 104 patients [51.9% men; mean age 57 years] with SBT. Histological type neuroendocrine tumor (NET) (43.7%, n=38), gastrointestinal stromal tumors (GIST) (21.8%, n=19), lymphoma (17.2%, n=15) and adenocarcinoma (AC) (11.5%, n=10). GIST was more frequent in duodenum (50%; n=12) and NET in the ileum (65.8%; n=25). Metastasis was observed in 17 cases, most commonly from colon and melanoma. Nausea and vomiting were significantly more often observed in AC (p=0.035), as well as gastrointestinal bleeding in GIST (p=0.007). The most common diagnostic tools were CT and CT enteroclysis with an elevated diagnostic yield (86% and 94% respectively). The 5-year survival of GIST, NET, lymphoma and AC were 94.7% (95%CI 68.1-99.2), 82.2% (95%CI 57.6-93.3), 40.0% (95%CI 16.5-82.8) and 25.9% (95%CI 4.5-55.7%), respectively. NET (HR 6.1; 95%CI 2.1-17.2) and GIST (HR 24.4; 95%CI 3.0-19.8) were independently associated with higher survival compared to AC, adjusted for age and sex.CONCLUSIONS:
Malignant SBT are rare conditions and NETs are the most common histological subtype. Clinical presentation at diagnosis, location or complications may suggest a more probable diagnosis. GIST and NET are associated with better survival compared to other malignant subtypes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hospitais Universitários
/
Neoplasias Intestinais
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Intestino Delgado
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do sul
/
Chile
Idioma:
En
/
Es
Revista:
Gastroenterol Hepatol
/
Gastroenterol. hepatol. (Ed. impr.)
/
Gastroenterologia y hepatologia (Ed. impresa)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Chile