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PAA-PU Janus Hydrogels Stabilized by Janus Particles and its Interfacial Performance During Hemostatic Processing.
Fang, Yan; Zheng, Yanyan; Chi, Chongyi; Jiang, Sai; Qin, Wanbang; Zhang, Yicheng; Liu, Haiqing; Chen, Qinhui.
Afiliação
  • Fang Y; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Zheng Y; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Chi C; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Jiang S; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Qin W; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Zhang Y; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Liu H; College of Chemistry and Materials Science, Fujian Normal University, Fuzhou, 350007, P. R. China.
  • Chen Q; Fujian Provincial Key Laboratory of Polymer Materials, Fujian Normal University, Fuzhou, 350007, P. R. China.
Adv Healthc Mater ; 13(13): e2303802, 2024 05.
Article em En | MEDLINE | ID: mdl-38341630
ABSTRACT
Hydrogel is a very promising dressing for hemostasis and wound healing due to its good adhesion and long-term moist environment. However, secondary injury caused by tissue adhesion due to homogeneous hydrogel cannot be ignored. The obvious interface existing in Janus hydrogel will weaken its asymmetric function. Here, a hierarchical adhesive polyacrylic acid-polyurushiol water-oil Janus hydrogel (JPs@PAA-PU) without adhesive layer is fabricated by one-pot method in the stabilization of polystyrene@silica-siliver Janus particles (JPs). The morphological structure, mechanical properties, anisotropic chemical composition, and adhesion performance, in vivo, and in vitro hemostatic properties of Janus hydrogel are investigated. Result shows that the obtained Janus hydrogel possesses obvious compartmentalization in microstructure, functional groups, and chemical elements. Janus hydrogel is provided with asymmetric interfacial toughness with top 52.45 ± 2.29 Kpa and bottom 7.04 ± 0.88 Kpa on porcine liver. The adhesion properties of PAA side to tissue, red blood cells and platelets, promoting effect of PU side on coagulation cascade reaction and its physical battier endow Janus hydrogel with shorter hemostatic time and less blood loss than control group. It also exhibits excellent antibacterial effects against Escherichia coli and Staphylococcus aureus (>90%). Janus hydrogel possesses biosafety, providing safety guarantee for clinical applications in the future.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resinas Acrílicas / Hidrogéis Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Resinas Acrílicas / Hidrogéis Limite: Animals Idioma: En Revista: Adv Healthc Mater Ano de publicação: 2024 Tipo de documento: Article