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Biomimetic delivery of emodin via macrophage membrane-coated UiO-66-NH2 nanoparticles for acute pancreatitis treatment.
Yang, Liuxuan; Liu, Xianbin; Yang, Jing; Wang, Ke; Ai, Zhenghao; Shang, Jinlu; Zhou, Meiling.
Afiliação
  • Yang L; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Liu X; Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang, 621000, China.
  • Yang J; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Wang K; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Ai Z; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Shang J; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Clinical Pharmacy, School of Pharmacy, Southwest Medical University, Luzhou, China.
  • Zhou M; Department of Pharmacy, The Affiliated Hospital of Southwest Medical University, Luzhou, China. Electronic address: meilzhou@163.com.
Biochem Biophys Res Commun ; 702: 149649, 2024 04 02.
Article em En | MEDLINE | ID: mdl-38341924
ABSTRACT
Acute pancreatitis (AP) is a severe inflammatory condition with a rising incidence and high mortality rates, especially in severe cases. Emodin (ED), known for its potent anti-inflammatory properties, holds promise in addressing AP. However, its clinical application is hindered by limitations such as low bioavailability and insufficient target specificity. Herein, we developed a novel drug delivery system using macrophage membrane-coated UiO-66-NH2 nanoparticles loaded with ED (MVs-UiO-ED). UiO-66-NH2 was successfully synthesized and characterized, revealing an octahedral structure with a suitable size distribution. The successful loading of ED onto UiO-66-NH2 was confirmed by ultraviolet and infrared spectroscopy. Subsequently, MVs-UiO-ED was prepared by coating macrophage membrane-derived vesicles onto UiO-ED, resulting in a biomimetic delivery system. In vitro release studies demonstrated that MVs-UiO-ED exhibited a sustained-release profile, indicating its potential for prolonged drug circulation. An AP mouse model was established to evaluate the therapeutic efficacy of MVs-UiO-ED. Compared with the model group, MVs-UiO-ED significantly reduced serum levels of α-amylase and lipase, two indicators of pancreatitis severity. Furthermore, histopathological examinations revealed that MVs-UiO-ED ameliorated pancreatic tissue damage. This study underscores the potential of MVs-UiO-ED as an effective therapeutic approach for AP.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Pancreatite / Ácidos Ftálicos / Emodina / Nanopartículas / Estruturas Metalorgânicas Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Pancreatite / Ácidos Ftálicos / Emodina / Nanopartículas / Estruturas Metalorgânicas Limite: Animals Idioma: En Revista: Biochem Biophys Res Commun Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China