Biofilm-mediated infections by multidrug-resistant microbes: a comprehensive exploration and forward perspectives.
Arch Microbiol
; 206(3): 101, 2024 Feb 14.
Article
em En
| MEDLINE
| ID: mdl-38353831
ABSTRACT
A biofilm is a collection of microorganisms organized in a matrix of extracellular polymeric material. Biofilms consist of microbial cells that attach to both surfaces and each other, whether they are living or non-living. These microbial biofilms can lead to hospital-acquired infections and are generally detrimental. They possess the ability to resist the human immune system and antibiotics. The National Institute of Health (NIH) states that biofilm formation is associated with 65% of all microbial illnesses and 80% of chronic illnesses. Additionally, non-device-related microbial biofilm infections include conditions like cystic fibrosis, otitis media, infective endocarditis, and chronic inflammatory disorders. This review aims to provide an overview of research on chronic infections caused by microbial biofilms, methods used for biofilm detection, recent approaches to combat biofilms, and future perspectives, including the development of innovative antimicrobial strategies such as antimicrobial peptides, bacteriophages, and agents that disrupt biofilms.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bacteriófagos
/
Infecção Hospitalar
/
Fibrose Cística
Limite:
Humans
Idioma:
En
Revista:
Arch Microbiol
/
Arch. microbiol
/
Archives of microbiology
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Egito