Single Euploid Embryo Transfer Outcomes After Uterine Septum Resection.
J Minim Invasive Gynecol
; 31(5): 432-437, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-38360394
ABSTRACT
STUDY OBJECTIVE:
To study pregnancy outcomes after single euploid embryo transfer (SEET) in patients who underwent prior uterine septum resection to those with uteri of normal contour, without Müllerian anomalies or uterine abnormalities including polyps or fibroids, and without a history of prior uterine surgeries.DESIGN:
Retrospective cohort study.SETTING:
Single academic affiliated center. PATIENTS 60 cycles of patients with prior hysteroscopic uterine septum resection who underwent an autologous SEET between 2012 and 2020 were used as the investigational cohort. A 31 ratio propensity score matched control cohort of 180 single euploid embryo transfer cycles from patients without a history of uterine septa were used as the control group.INTERVENTIONS:
No interventions administered. MEASUREMENTS AND MAINRESULTS:
Pregnancy, clinical pregnancy loss, ongoing clinical pregnancy, and live birth rates in patients with a history of uterine septum resection compared with matched patients without Müllerian anomalies or uterine surgeries. Patients with a prior uterine septum had significantly lower rates of chemical pregnancy (58.33% vs 77.2%, p = .004), implantation (41.67% vs 65.6%, p = .001), and live birth (33.33% vs 57.8%, p = .001) per transfer. No statistical difference in clinical pregnancy loss rates was found when comparing septum patients with controls (8.33% vs 7.8%, p = .89).CONCLUSION:
Patients with a history of hysteroscopic resection who undergo in vitro fertilization are more susceptible to suboptimal clinical outcomes compared with patients with normal uteri. Early pregnancy loss rates in patients with a uterine septum are higher than in those without; however, after resection, the rates are comparable. Patients born with septate uteri require assessment of surgical intervention prior to SEET, and to optimize their reproductive outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transferência de Embrião Único
/
Útero Septado
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
/
Humans
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Pregnancy
Idioma:
En
Revista:
J Minim Invasive Gynecol
/
J. minim. invasive gynecol
/
Journal of minimally invasive gynecology
Assunto da revista:
GINECOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article