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Microbiome and its relevance to indigenous inflammatory bowel diseases in China.
Han, Anqi; Yang, Mingya; Chen, Bo; Cao, Guodong; Xu, Junrui; Meng, Tao; Liu, Yu; Wang, Zhenzhen; Zhou, Yangliu; Xu, Na; Han, Wei; Sun, Haiyi; Mei, Qiao; Zhu, Lixin; Xiong, Maoming.
Afiliação
  • Han A; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Yang M; Department of Haematology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Chen B; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Cao G; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Xu J; Department of Thoracic Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Meng T; Department of General Surgery, The Third Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Liu Y; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Wang Z; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Zhou Y; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Xu N; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Han W; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China.
  • Sun H; Clinical Medical Collage, Anhui Medical University, Hefei 230020, PR China.
  • Mei Q; Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China. Electronic address: meiqiao@hotmail.com.
  • Zhu L; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China. Electronic address: zhulixin@ahmu.edu.cn.
  • Xiong M; Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, PR China. Electronic address: xiongmd@aliyun.com.
Gene ; 909: 148257, 2024 May 30.
Article em En | MEDLINE | ID: mdl-38367851
ABSTRACT

BACKGROUND:

Inflammatory Bowel Disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract with an unknown etiology. Although dysbiosis is implicated in its pathogenesis, deep sequencing and oral microbiota study in Chinese IBD patients is absent.

AIM:

To explore the role of oral / intestinal microbiota in patients with IBD and the potential associations therein.

METHODS:

Clinical data, fecal and saliva samples were harvested from 80 patients with IBD (Crohn's disease, CD, n = 69; Ulcerative colitis, UC, n = 11) and 24 normal controls. Microbiomics (16S rRNA sequencing and 16S rRNA full-length sequencing) were used to detect and analyze the difference between IBD patients and normal control.

RESULTS:

Compared with normal controls, a higher abundance of the intestinal Shigella spp. (Shigella flexneri and Shigella sonnei, which were positively relate to the severity of IBD), lower abundance of intestinal probiotics (Prevotella, Faecalibacterium and Roseburia), and higher abundance of oral Neisseria were present in IBD patients with microbiome. The higher inflammation-related markers, impaired hepatic and renal function, and dyslipidaemia were present in patients with IBD. A higher intake of red meat and increased abundance of Clostridium in the gut were found in CD patients, while the elevated abundance of Ruminococcus in the gut was showed in UC ones. The bacterial composition of saliva and fecal samples was completely different, yet there was some correlation in the distribution of dominant probiotics.

CONCLUSION:

Enteric dysbacteriosis and the infections of pathogenic bacteria (Shigella) may associate with the occurrence or development of IBD.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn / Microbiota Limite: Humans Idioma: En Revista: Gene Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Doenças Inflamatórias Intestinais / Colite Ulcerativa / Doença de Crohn / Microbiota Limite: Humans Idioma: En Revista: Gene Ano de publicação: 2024 Tipo de documento: Article