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Murepavadin promotes the killing efficacies of aminoglycoside antibiotics against Pseudomonas aeruginosa by enhancing membrane potential.
Wei, Xiaoya; Gao, Jiacong; Zhou, Dandan; Xu, Congjuan; Chen, Ping; Chen, Shuiping; Zhang, Yanhong; Liu, Xuehua; Li, Guanxian; Zhu, Guangbo; Liu, Huimin; Li, Jinjin; Geng, Bin; Gao, Linlin; Cheng, Zhihui; Lamont, Iain L; Pletzer, Daniel; Jin, Yongxin; Jin, Shouguang; Wu, Weihui.
Afiliação
  • Wei X; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Gao J; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Zhou D; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Xu C; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Chen P; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Chen S; Department of Laboratory Medicine, 5th Medical Center of PLA General Hospital, Beijing, China.
  • Zhang Y; Nankai University Affiliated Hospital (Tianjin Forth Hospital), Tianjin, China.
  • Liu X; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Li G; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Zhu G; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Liu H; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Li J; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Geng B; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Gao L; Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China.
  • Cheng Z; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Lamont IL; Department of Biochemistry, University of Otago, Dunedin, New Zealand.
  • Pletzer D; Department of Microbiology and Immunology, University of Otago, Dunedin, New Zealand.
  • Jin Y; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Jin S; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
  • Wu W; State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Molecular Microbiology and Technology of the Ministry of Education, Department of Microbiology, College of Life Sciences, Nankai University, Tianjin, China.
Antimicrob Agents Chemother ; 68(4): e0153923, 2024 Apr 03.
Article em En | MEDLINE | ID: mdl-38470195
ABSTRACT
Murepavadin is a peptidomimetic that specifically targets the lipopolysaccharide transport protein LptD of Pseudomonas aeruginosa. Here, we found that murepavadin enhances the bactericidal efficacies of tobramycin and amikacin. We further demonstrated that murepavadin enhances bacterial respiration activity and subsequent membrane potential, which promotes intracellular uptake of aminoglycoside antibiotics. In addition, the murepavadin-amikacin combination displayed a synergistic bactericidal effect in a murine pneumonia model.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Infecções por Pseudomonas / Amicacina Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Infecções por Pseudomonas / Amicacina Limite: Animals Idioma: En Revista: Antimicrob Agents Chemother Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China