AuNPs with Cynara scolymus leaf extracts rescue arsenic-induced neurobehavioral deficits and hippocampal tissue toxicity in Balb/c mice through D1R and D2R activation.
Environ Toxicol Pharmacol
; 107: 104417, 2024 Apr.
Article
em En
| MEDLINE
| ID: mdl-38493879
ABSTRACT
The present study was designed to evaluate whether AuNPs (gold nanoparticles) synthesized with the Cynara scolymus (CS) leaf exert protective and/or alleviative effects on arsenic (As)-induced hippocampal neurotoxicity in mice. Neurotoxicity in mice was developed by orally treating 10â¯mg/kg/day sodium arsenite (NaAsO2) for 21 days. 10⯵g/g AuNPs, 1.6â¯g/kg CS, and 10⯵g/g CS-AuNPs were administered orally simultaneously with 10â¯mg/kg As. CS and CS-AuNPs treatments showed down-regulation of TNF-α and IL-1ß levels. CS and CS-AuNPs also ameliorated apoptosis and reduced the alterations in the expression levels of D1 and D2 dopamine receptors induced by As. Simultaneous treatment with CS and CS-AuNPs improved As-induced learning, memory deficits, and motor coordination in mice assessed by water maze and locomotor tests, respectively. The results of this study provide evidence that CS-AuNPs demonstrated neuroprotective roles with antioxidant, anti-inflammatory, and anti-apoptotic effects, as well as improving D1 and D2 signaling, and eventually reversed neurobehavioral impairments.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Arsênio
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Extratos Vegetais
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Cynara scolymus
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Nanopartículas Metálicas
Limite:
Animals
Idioma:
En
Revista:
Environ Toxicol Pharmacol
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Environ. toxicol. pharmacol
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Environmental toxicology and pharmacology
Ano de publicação:
2024
Tipo de documento:
Article