Changes in intraocular pressure following intravitreal dexamethasone implant in patients with history of glaucoma filtration surgery.
Graefes Arch Clin Exp Ophthalmol
; 262(9): 2845-2850, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38578333
ABSTRACT
PURPOSE:
This study aimed to evaluate changes in intraocular pressure following intravitreal dexamethasone implant injection, specifically in patients undergoing glaucoma filtration surgery.METHODS:
The degree of increase in intraocular pressure was compared retrospectively among three groups. Group 1 comprised patients who underwent prior glaucoma filtration surgery (54 eyes). Group 2 included patients with or suspected glaucoma without such surgical history (20 eyes). Group 3 included patients without glaucoma (33 eyes). Pressure measurements were taken before the injection and at 1, 2, 3, and 6 months post-injection. A subgroup analysis was performed for pressure > 35 mmHg, > 30 mmHg, > 25 mmHg, and a difference > 10 mmHg between the peak and baseline pressure.RESULTS:
Group 1 consistently displayed lower pressures compared with Group 2, with significant difference at both 1- and 6-month post-injections (15.09 mmHg vs. 18.10 mmHg, P = 0.042 and 13.91 mg vs. 17.25 mmHg, P = 0.040). The proportion of patients in Group 1 and Group 3 with pressures > 25 mmHg, > 30 mmHg, and a difference > 10 mmHg did not significantly differ (15.6% vs. 9.5%, P = 0.231; 3.1% vs. 2.3%, P = 0.867; and 17.1% vs. 7.1%, P = 0.231). Notably, Group 2 exhibited a significantly higher proportion within each category (> 25 mmHg, 24.0%; > 30 mmHg, 20.0%; > 10 mmHg difference, 28.0%).CONCLUSION:
Intravitreal dexamethasone implant did not increase the risk of elevated intraocular pressure in patients with a history of glaucoma filtration surgery compared with patients with suspected glaucoma; the risk was similar to those without glaucoma.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dexametasona
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Glaucoma
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Cirurgia Filtrante
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Implantes de Medicamento
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Injeções Intravítreas
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Glucocorticoides
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Pressão Intraocular
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Graefe's archive for clinical and experimental ophthalmology
/
Graefes Arch Clin Exp Ophthalmol
/
Graefes arch. clin. exp. ophthalmol
Ano de publicação:
2024
Tipo de documento:
Article