Can irisin be developed as the molecular evolutionary clock based on the origin and functions?
Gen Comp Endocrinol
; 352: 114515, 2024 06 01.
Article
em En
| MEDLINE
| ID: mdl-38582177
ABSTRACT
Irisin, a myokine identified in 2012, has garnered research interest for its capacity to induce browning of adipocytes and improve metabolic parameters. As such, the potential therapeutic applications of this exercise-induced peptide continue to be explored. Though present across diverse animal species, sequence analysis has revealed subtle variation in the irisin protein. In this review, we consider the effects of irisin on disease states in light of its molecular evolution. We summarize current evidence for irisin's influence on pathologies and discuss how sequence changes may inform development of irisin-based therapies. Furthermore, we propose that the phylogenetic variations in irisin could potentially be leveraged as a molecular clock to elucidate evolutionary relationships.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibronectinas
/
Adipócitos
Limite:
Animals
Idioma:
En
Revista:
Gen Comp Endocrinol
/
Gen. comp. endocrinol
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General and comparative endocrinology
Ano de publicação:
2024
Tipo de documento:
Article