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Effects and mechanisms of endocrine disruptor bisphenol AF on male reproductive health: A mini review.
Xue, Senlin; Li, Xiaotian; Zhou, Shenrui; Zhang, Ji; Sun, Kun; Peng, Xin; Chen, Nannan; Dong, Mengmeng; Jiang, Tingwang; Chen, Yang; Yan, Wei.
Afiliação
  • Xue S; Department of Key Laboratory, Affiliated hospital of Nantong University, Changshu 215500, PR China.
  • Li X; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Zhou S; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Zhang J; Cancer and Anticancer Drug Research Center, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325035, PR China.
  • Sun K; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Peng X; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Chen N; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Dong M; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China.
  • Jiang T; Department of Key Laboratory, Affiliated hospital of Nantong University, Changshu 215500, PR China.
  • Chen Y; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China. Electronic address: cheny339@xzhmu.edu.cn.
  • Yan W; Xuzhou Engineering Research Center of Medical Genetics and Transformation, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics, School of life science, Xuzhou Medical University, Xuzhou, Jiangsu 221004, PR China. Electronic address: yanwei@xzhmu.edu.cn.
Ecotoxicol Environ Saf ; 276: 116300, 2024 May.
Article em En | MEDLINE | ID: mdl-38583312
ABSTRACT
Bisphenol AF (BPAF), an analogue of bisphenol A (BPA), is commonly found in manufacturing industries and known for its endocrine-disrupting properties. Despite potential similarities in adverse effects with BPA, limited toxicological data exist specifically for BPAF and its impact on male reproductive physiology. This mini-review aims to elucidate the influence of BPAF on the male reproductive system, focusing on estrogenic effects, effects on the hypothalamus-pituitary-gonad (HPG) axis, steroidogenesis, spermatogenesis, and transgenerational reproductive toxicity. Additionally, we outline the current insights into the potential mechanisms underlying BPAF-induced male reproductive disorders. BPAF exposure, either directly or maternally, has been associated with detrimental effects on male reproductive functions, including damage to the blood-testis barrier (BTB) structure, disruptions in steroidogenesis, testis dysfunction, decreased anogenital distance (AGD), and defects in sperm and semen quality. Mechanistically, altered gene expression in the HPG axis, deficits in the steroidogenesis pathway, activation of the aromatase pathway, cascade effects induced by reactive oxygen species (ROS), activation of ERK signaling, and immunological responses collectively contribute to the adverse effects of BPAF on the male reproductive system. Given the high prevalence of male reproductive issues and infertility, along with the widespread environmental distribution of bisphenols, this study provides valuable insights into the negative effects of BPAF. The findings underscore the importance of considering the safe use of this compound, urging further exploration and regulatory attention to decrease potential risks associated with BPAF exposure.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Compostos Benzidrílicos / Disruptores Endócrinos / Fluorocarbonos Limite: Animals / Humans / Male Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fenóis / Compostos Benzidrílicos / Disruptores Endócrinos / Fluorocarbonos Limite: Animals / Humans / Male Idioma: En Revista: Ecotoxicol Environ Saf Ano de publicação: 2024 Tipo de documento: Article