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The association between leptin and diabetes: A meta-analysis.
Wu, Xin-Yu; Song, Han-Bing; Wang, Jian-Wei.
Afiliação
  • Wu XY; Department of Traditional Chinese Medicine, School of Basic Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
  • Song HB; Department of Orthopedics, First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
  • Wang JW; Department of Traditional Chinese Medicine, School of Basic Medicine, Heilongjiang University of Traditional Chinese Medicine, Harbin, China.
J Obstet Gynaecol Res ; 50(7): 1126-1131, 2024 Jul.
Article em En | MEDLINE | ID: mdl-38594218
ABSTRACT

PURPOSE:

The study object was to determine the relationship between leptin and diabetes.

METHODS:

We searched for the literature on the relationship between leptin and diabetes from PubMed, EMBASE, Cochrane Library, and CNKI databases. We carried out the meta-analysis by calculating the Std. Mean Difference (SMD) and 95% confidence intervals (CIs) to study the relationship between leptin and diabetes. We performed the Chi-square-based Q test and I2 statistics to evaluate the potential heterogeneity, and the sensitivity analysis was performed to evaluate the stability of our results. Moreover, Begg's test was performed to evaluate the publication bias.

RESULTS:

There are 10 studies in this study for meta-analysis, which include 1879 patients (diabetic (n = 1024); and nondiabetic patients (n = 855)). The results indicated that the levels of serum leptin were significantly increased in patients with diabetes (SMD = 1.78, 95% CI [0.81, 2.76]), especially those with gestational diabetes mellitus compared with controls (SMD = 3.03, 95% CI [1.21, 4.86]). However, the results showed that there was no difference in serum leptin levels between type 2 diabetes and controls (SMD = 0.34, 95% CI [-1.06, 1.74]).

CONCLUSIONS:

Our analysis indicated that the levels of serum leptin were significantly elevated in patients with diabetes especially those with gestational diabetes mellitus compared with controls.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Leptina / Diabetes Mellitus Tipo 2 Limite: Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Diabetes Gestacional / Leptina / Diabetes Mellitus Tipo 2 Limite: Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Res Assunto da revista: GINECOLOGIA / OBSTETRICIA Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China