Impact of Ramadan fasting on lipid profile, uric acid, and HbA1c in CKD: A systematic review and meta-analysis.

ABSTRACT

Studies have shown that fasting during Ramadan has different effects on circulating levels of several biochemical markers. This study aims to conduct a comprehensive evaluation of studies related to the effect of fasting in the holy month of Ramadan on lipid profile, uric acid, and HbA1c in CKD patients. Studies were systematically searched and collected from three databases (PubMed, Scopus, and Web of Science). After screening, the quality and risk of bias assessment of the selected articles were evaluated. Study heterogeneity was assessed using the Cochrane test and I² statistic. In case of any heterogeneity random effects model with the inverse-variance method was applied. All analyses were performed using STATA software version 16. Four observational studies were included in this study. The results of this meta-analysis were that cholesterol (Weighted mean differences (WMD)0.21 with 95% CI-0.09-0.51 (P-value=0.18)), LDL (WMD0.06 with 95% CI -0.24-0.36 (P-value0.69)), triglyceride (WMD0.05 with 95% CI-0.25-0.35 (P-value0.73)) had not-significant increase. Uric acid (WMD -0.11 with 95% CI -0.42-0.21 (P-value0.51)) and HbA1c (WMD -0.22 with 95% CI -0.79-0.36 (P-value 0.46)) show a non-significant decrease. The results of the analyses did not report significant changes in the lipid profile, uric acid, and HbA1c in CKD patients after Ramadan fasting.