Entangling and disentangling mitotic chromosomes.

Baxter, Jonathan

Baxter, Jonathan.

Afiliação

Baxter J; Genome Damage and Stability Centre, School of Life Sciences, Science Park Road, University of Sussex, Falmer, Brighton, East Sussex BN1 9RQ, UK. Electronic address: jon.baxter@sussex.ac.uk.

Mol Cell ; 84(8): 1398-1400, 2024 Apr 18.

Article em En | MEDLINE | ID: mdl-38640891

ABSTRACT

ABSTRACT

The DNA topological challenges generated by cellular manipulation of extremely long DNA fibers remain poorly understood. In this issue of Molecular Cell, Hildebrand et al.1 describe how mitotic chromosomes are self entangled and that disentanglement requires TOP2 activity in late mitosis.

Assuntos

Cromossomos; DNA Topoisomerases Tipo II; DNA Topoisomerases Tipo II/genética; Cromossomos/genética; DNA/genética; Mitose/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromossomos / DNA Topoisomerases Tipo II Idioma: En Revista: Mol Cell Assunto da revista: BIOLOGIA MOLECULAR Ano de publicação: 2024 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google