Curcumin nanogel and its efficacy against oxidative stress and inflammation in rat models of ischemic stroke.
Nanomedicine (Lond)
; 19(12): 1069-1085, 2024.
Article
em En
| MEDLINE
| ID: mdl-38661738
ABSTRACT
Aim:
The study was designed to develop and analyze curcumin nanoparticles.Methods:
Curcumin nanoparticles were formulated and evaluated. Their efficacy in protecting against brain damage was investigated in a rat model of ischemic stroke, considering motor function, muscle strength and antioxidant enzyme activity.Results:
Curcumin nanoparticles displayed a zeta potential of -55 ± 13.5 mV and an average particle size of 51.40 ± 21.70 nm. In ischemic stroke rat models, curcumin nanoparticle treatment significantly improved motor functions, and muscle strength and increased the activities of antioxidant enzymes like glutathione peroxidase, glutathione, glutathione S-transferase, superoxide dismutase and catalase, reducing oxidative stress and inflammation.Conclusion:
Curcumin nanoparticles showed significant neuroprotective effects in ischemic stroke models.
[Box see text].
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estresse Oxidativo
/
Curcumina
/
Modelos Animais de Doenças
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AVC Isquêmico
/
Inflamação
/
Antioxidantes
Limite:
Animals
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Arábia Saudita