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European clinical practice guidelines for the definition, diagnosis, and treatment of oligometastatic esophagogastric cancer (OMEC-4).
Kroese, Tiuri E; Bronzwaer, Sebastiaan; van Rossum, Peter S N; Schoppman, Sebastian F; Deseyne, Pieter R A J; van Cutsem, Eric; Haustermans, Karin; Nafteux, Philippe; Thomas, Melissa; Obermannova, Radka; Mortensen, Hanna R; Nordsmark, Marianne; Pfeiffer, Per; Elme, Anneli; Adenis, Antoine; Piessen, Guillaume; Bruns, Christiane J; Lordick, Florian; Gockel, Ines; Moehler, Markus; Gani, Cihan; Liakakos, Theodore; Reynolds, John V; Morganti, Alessio G; Rosati, Riccardo; Castoro, Carlo; Cellini, Francesco; D'Ugo, Domenico; Roviello, Franco; Bencivenga, Maria; de Manzoni, Giovanni; van Berge Henegouwen, Mark I; Hulshoff, Maarten C C M; van Dieren, Jolanda; Vollebergh, Marieke; van Sandick, Johanna W; Jeene, Paul; Muijs, Christel; Slingerland, Marije; Voncken, Francine E M; Hartgrink, Henk; Creemers, Geert-Jan; van der Sangen, Maurice J C; Nieuwenhuijzen, Grard A P; Berbee, Maaike; Verheij, Marcel; Wijnhoven, Bas; Beerepoot, Laurens V; Mohammad, Nadia Haj; Mook, Stella.
Afiliação
  • Kroese TE; Department of Radiation Oncology, University Hospital Zurich, University of Zurich, Zurich, Switzerland; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Ut
  • Bronzwaer S; Department of Surgery, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: r.vanhillegersberg@umcutrecht.nl.
  • van Rossum PSN; Department of Radiation Oncology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
  • Schoppman SF; Department of Surgery, Medical University of Vienna, Vienna University, Vienna, Austria.
  • Deseyne PRAJ; Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • van Cutsem E; Department of Medical Oncology, KU Leuven, Leuven University, Leuven, Belgium.
  • Haustermans K; Department of Radiation Oncology, KU Leuven, Leuven University, Leuven, Belgium.
  • Nafteux P; Department of Surgery, KU Leuven, Leuven University, Leuven, Belgium.
  • Thomas M; Department of Radiation Oncology, AZ Sint-Maarten, Mechelen, Belgium.
  • Obermannova R; Department of Comprehensive Cancer Care, Masaryk Memorial Cancer Institute and Faculty of Medicine, Masaryk, University Brno, Brno, Czech Republic.
  • Mortensen HR; Danish Center of Particle Therapy, Aarhus University Medical Center, Aarhus University, Aarhus, Denmark.
  • Nordsmark M; Department of Oncology, Aarhus University Hospital, Aarhus University, Aarhus, Denmark.
  • Pfeiffer P; Department of Medical Oncology, Odense University Medical Center, University of Odense, Odense, Denmark.
  • Elme A; Department of Medical Oncology, Tallinn University Hospital, Tallinn University, Tallinn, Estonia.
  • Adenis A; Department of Medical Oncology, IRCM, Inserm, Université Montpellier, ICM, Montpellier, France.
  • Piessen G; Department of Surgery, Univ. Lille, CNRS, Inserm, CHU Lille, UMR9020-U1277 - CANTHER - Cancer Heterogeneity Plasticity and Resistance to Therapies, F-59000 Lille, France.
  • Bruns CJ; Department of Surgery, University Hospital Cologne, University of Cologne, Cologne, Germany.
  • Lordick F; Department of Medical Oncology, University Hospital Leipzig, University of Leipzig, Leipzig Germany.
  • Gockel I; Department of Visceral, Transplant, Thoracic and Vascular Surgery, University Hospital Leipzig, University of Leipzig, Leipzig, Germany.
  • Moehler M; Department of Medicine, Johannes Gutenberg-University Clinic, University of Mainz, Mainz, Germany.
  • Gani C; Department of Radiation Oncology, University Hospital Tubingen, University of Tubingen, Tubingen, Germany.
  • Liakakos T; Department of Surgery, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Reynolds JV; Trinity St James's Cancer Institute, St. James Hospital, Trinity College Dublin, Dublin, Ireland.
  • Morganti AG; Department of Radiation Oncology, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy; Department of Radiation Oncology, DIMES, Alma Mater Studiorum - Bologna University, Bologna, Italy.
  • Rosati R; Department of GI Surgery, IRCCS San Raffaele Scientific Institute, San Raffaele Vita-salute University, Milan, Italy.
  • Castoro C; Department of Biomedical Sciences, Humanitas University, Via Rita Levi Montalcini 4, Pieve Emanuele, Milan 20072, Italy; Upper GI and General Surgery Division, Department of Surgery IRCCS Humanitas Research Hospital, via Manzoni 56, Rozzano, Milan 20089, Italy.
  • Cellini F; Università Cattolica del Sacro Cuore, Dipartimento Universitario Diagnostica per immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy; Fondazione Policlinico Universitario "A. Gemelli" IRCCS, Dipartimento di Diagnostica per Immagini, Radioterapia Oncologica ed Ematologia, Roma, Italy.
  • D'Ugo D; Department of Surgery, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy.
  • Roviello F; Department of Surgery, Siena University Hospital, University of Siena, Siena, Italy.
  • Bencivenga M; General and Upper GI Division, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
  • de Manzoni G; General and Upper GI Division, Department of Surgery, Dentistry, Paediatrics and Gynaecology, University of Verona, Verona, Italy.
  • van Berge Henegouwen MI; Department of Surgery, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
  • Hulshoff MCCM; Department of Radiation Oncology, Amsterdam UMC, location VUmc, Amsterdam, the Netherlands.
  • van Dieren J; Department of Gastrointestinal Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Vollebergh M; Department of Medical Oncology, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • van Sandick JW; Department of Surgery, Antoni van Leeuwenhoek, Netherlands Cancer Institute, Amsterdam, the Netherlands.
  • Jeene P; Department of Radiation Oncology, Radiotherapiegroep, Deventer, the Netherlands.
  • Muijs C; Department of Radiation Oncology, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
  • Slingerland M; Department of Medical Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
  • Voncken FEM; Department of Radiation Oncology, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
  • Hartgrink H; Department of Surgery, University Medical Center Leiden, University of Leiden, Leiden, the Netherlands.
  • Creemers GJ; Department of Medical Oncology, Catharina Cancer Institute, Eindhoven, the Netherlands.
  • van der Sangen MJC; Department of Radiation Oncology, Catharina Cancer Institute, Eindhoven, the Netherlands.
  • Nieuwenhuijzen GAP; Department of Surgery, Catharina Cancer Institute, Eindhoven, the Netherlands.
  • Berbee M; Department of Radiation Oncology (MAASTRO), GROW School for Oncology and Developmental Biology, Maastricht, the Netherlands.
  • Verheij M; Department of Radiation Oncology, Radboud University Medical Center, Nijmegen, the Netherlands.
  • Wijnhoven B; Department of Surgery, Erasmus University Medical Center, University of Rotterdam, Rotterdam, the Netherlands.
  • Beerepoot LV; Department of Medical Oncology, Elisabeth Tweesteden Ziekenhuis Tilburg, the Netherlands.
  • Mohammad NH; Department of Medical Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
  • Mook S; Department of Radiation Oncology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands.
Eur J Cancer ; 204: 114062, 2024 Jun.
Article em En | MEDLINE | ID: mdl-38678762
ABSTRACT

INTRODUCTION:

The OligoMetastatic Esophagogastric Cancer (OMEC) project aims to provide clinical practice guidelines for the definition, diagnosis, and treatment of esophagogastric oligometastatic disease (OMD).

METHODS:

Guidelines were developed according to AGREE II and GRADE principles. Guidelines were based on a systematic review (OMEC-1), clinical case discussions (OMEC-2), and a Delphi consensus study (OMEC-3) by 49 European expert centers for esophagogastric cancer. OMEC identified patients for whom the term OMD is considered or could be considered. Disease-free interval (DFI) was defined as the time between primary tumor treatment and detection of OMD.

RESULTS:

Moderate to high quality of evidence was found (i.e. 1 randomized and 4 non-randomized phase II trials) resulting in moderate recommendations. OMD is considered in esophagogastric cancer patients with 1 organ with ≤ 3 metastases or 1 involved extra-regional lymph node station. In addition, OMD continues to be considered in patients with OMD without progression in number of metastases after systemic therapy. 18F-FDG PET/CT imaging is recommended for baseline staging and for restaging after systemic therapy when local treatment is considered. For patients with synchronous OMD or metachronous OMD and a DFI ≤ 2 years, recommended treatment consists of systemic therapy followed by restaging to assess suitability for local treatment. For patients with metachronous OMD and DFI > 2 years, upfront local treatment is additionally recommended.

DISCUSSION:

These multidisciplinary European clinical practice guidelines for the uniform definition, diagnosis and treatment of esophagogastric OMD can be used to standardize inclusion criteria in future clinical trials and to reduce variation in treatment.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias Esofágicas Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Eur J Cancer Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Neoplasias Esofágicas Limite: Humans País/Região como assunto: Europa Idioma: En Revista: Eur J Cancer Ano de publicação: 2024 Tipo de documento: Article