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Chronic high-dose testosterone impairs economic decision making, but has no effect on memory in male rats.
Wood, Ruth I; Chen, Michael Y; Snow, Elizabeth.
Afiliação
  • Wood RI; Department of Integrative Anatomical Sciences, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, United States. Electronic address: riw@usc.edu.
  • Chen MY; Department of Integrative Anatomical Sciences, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, United States.
  • Snow E; Department of Integrative Anatomical Sciences, Keck School of Medicine at the University of Southern California, Los Angeles, CA 90033, United States.
Behav Processes ; 218: 105044, 2024 May.
Article em En | MEDLINE | ID: mdl-38679343
ABSTRACT
The goal is to understand consequences of anabolic-androgenic steroid (AAS) abuse on cognitive function, using rats as a model. Economic decision making was evaluated in an operant test of effort value discounting, where subjects choose between 2 levers that deliver large and small rewards differing in maximum value and reward contrast. The hypothesis is that chronic high-dose testosterone increases preference for large rewards. Male rats were treated chronically with testosterone (7.5 mg/kg) or vehicle. Initially, all rats preferred the large reward lever when large and small rewards remained fixed at 3 and 1 sugar pellets, respectively. When different reward values were introduced, and with increasing response requirements, testosterone-treated rats made fewer responses for the large reward, and increased omissions. They earned fewer rewards overall. To determine if testosterone impairs memory, rats were tested for recognition memory with the novel object recognition and social transmission of food preference tasks, and for spatial memory with the radial arm maze and Morris water maze. There was not effect of chronic high-dose testosterone on any memory task. These results suggest that testosterone shifts economic decision making towards larger rewards even when they are disadvantageous, but does not alter memory in rats.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recompensa / Testosterona / Tomada de Decisões Limite: Animals Idioma: En Revista: Behav Processes Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Recompensa / Testosterona / Tomada de Decisões Limite: Animals Idioma: En Revista: Behav Processes Ano de publicação: 2024 Tipo de documento: Article