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A thermally reversible injectable adhesive for intestinal tissue repair and anti-postoperative adhesion.
Zhang, Wenmo; Zhang, Runze; Yang, Rong; Sun, Yage; Zhang, Qian; Feng, Xuequan; Cui, Chunyan; Liu, Wenguang.
Afiliação
  • Zhang W; School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China. cycui@tju.edu.cn.
  • Zhang R; NHC Key Laboratory of Critical Care Medicine, Department of Neurosurgery, Binhai Hospital of Tianjin Medical University General Hospital, Tianjin 300480, China.
  • Yang R; School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China. cycui@tju.edu.cn.
  • Sun Y; School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China. cycui@tju.edu.cn.
  • Zhang Q; School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China. cycui@tju.edu.cn.
  • Feng X; Tianjin First Center Hospital, Tianjin 300192, China. fengxuequan@126.com.
  • Cui C; School of Material Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China. cycui@tju.edu.cn.
  • Liu W; State Key Laboratory of Molecular Engineering of Polymers (Fudan University), China.
Biomater Sci ; 12(12): 3141-3153, 2024 Jun 11.
Article em En | MEDLINE | ID: mdl-38687002
ABSTRACT
Intestine damage is an acute abdominal disease that usually requires emergency sealing. However, traditional surgical suture not only causes secondary damage to the injured tissue, but also results in adhesion with other tissues in the abdominal cavity. To this end, a thermally reversible injectable gelatin-based hydrogel adhesive (GTPC) is constructed by introducing transglutaminase (TGase) and proanthocyanidins (PCs) into a gelatin system. By reducing the catalytic activity of TGase, the density of covalent and hydrogen bond crosslinking in the hydrogel can be regulated to tune the sol-gel transition temperature of gelatin-based hydrogels above the physiological temperature (42 °C) without introducing any synthetic small molecules. The GTPC hydrogel exhibits good tissue adhesion, antioxidant, and antibacterial properties, which can effectively seal damaged intestinal tissues and regulate the microenvironment of the damaged site, promoting tissue repair and regeneration. Intriguingly, temperature-induced hydrogen bond disruption and reformation confer the hydrogel with asymmetric adhesion properties, preventing tissue adhesion when applied in vivo. Animal experiment outcomes reveal that the GTPC hydrogel can seal the damaged intestinal tissue firmly, accelerate tissue healing, and efficiently prevent postoperative adhesion.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Temperatura / Hidrogéis / Gelatina / Intestinos Limite: Animals Idioma: En Revista: Biomater Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Temperatura / Hidrogéis / Gelatina / Intestinos Limite: Animals Idioma: En Revista: Biomater Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China