Earlier detection of gestational diabetes impacts on medication requirements, neonatal and maternal outcomes.
Diabetes Obes Metab
; 26(8): 3110-3118, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38699781
ABSTRACT
AIM:
Gestational diabetes (GD) is a global health concern with significant implications for maternal and neonatal outcomes. This study investigates the association between early GD (eGD) diagnosis (<24 weeks), pharmacotherapy requirements and adverse neonatal outcomes. MATERIALS ANDMETHODS:
A cohort of 369 pregnant women underwent a 75-g oral glucose tolerance test. Maternal variables, pharmacotherapy prescriptions and neonatal outcomes were analysed employing t-tests, χ2 tests, and logistic regression. A p < .05 was considered significant.RESULTS:
Early GD increased the odds of neonatal hypoglycaemia [odds ratio (OR) 18.57, p = .013] and respiratory distress syndrome (OR 4.75, p = .034). Nutritional therapy prescription by an accredited nutritionist was the most common treatment in women diagnosed after 24 weeks, but those with eGD required more frequently specialized nutritional consulting + metformin to achieve glycaemic control (p = .027). eGD was associated with a higher requirement of nutritional therapy prescription + metformin (OR 2.26, 95% confidence interval 1.25-4.09, p = .007) and with maternal hyperglycaemia during the post-partum period at 2 h of the oral glucose tolerance test (OR 1.03, 95% confidence interval 1.02-1.13, p = .024).CONCLUSION:
Timely diagnosis and personalized treatment of GD are desirable because an earlier presentation is related to a higher risk of adverse neonatal and maternal outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Diabetes Gestacional
/
Diagnóstico Precoce
/
Teste de Tolerância a Glucose
/
Hipoglicemiantes
/
Metformina
Limite:
Adult
/
Female
/
Humans
/
Newborn
/
Pregnancy
Idioma:
En
Revista:
Diabetes Obes Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
México