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Emerging biomarkers and molecular targets for precision medicine in cervical cancer.
Garg, Pankaj; Krishna, Madhu; Subbalakshmi, Ayalur Raghu; Ramisetty, Sravani; Mohanty, Atish; Kulkarni, Prakash; Horne, David; Salgia, Ravi; Singhal, Sharad S.
Afiliação
  • Garg P; Department of Chemistry, GLA University, Mathura, Uttar Pradesh 281406, India.
  • Krishna M; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Subbalakshmi AR; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Ramisetty S; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Mohanty A; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Kulkarni P; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Horne D; Departments of Molecular Medicine, Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Salgia R; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA.
  • Singhal SS; Departments of Medical Oncology & Therapeutics Research and Beckman Research Institute of City of Hope, Comprehensive Cancer Center and National Medical Center, Duarte, CA 91010, USA. Electronic address: ssinghal@coh.org.
Biochim Biophys Acta Rev Cancer ; 1879(3): 189106, 2024 May.
Article em En | MEDLINE | ID: mdl-38701936
ABSTRACT
Cervical cancer remains a significant global health burden, necessitating innovative approaches for improved diagnostics and personalized treatment strategies. Precision medicine has emerged as a promising paradigm, leveraging biomarkers and molecular targets to tailor therapy to individual patients. This review explores the landscape of emerging biomarkers and molecular targets in cervical cancer, highlighting their potential implications for precision medicine. By integrating these biomarkers into comprehensive diagnostic algorithms, clinicians can identify high-risk patients at an earlier stage, enabling timely intervention and improved patient outcomes. Furthermore, the identification of specific molecular targets has paved the way for the development of targeted therapies aimed at disrupting key pathways implicated in cervical carcinogenesis. In conclusion, the evolving landscape of biomarkers and molecular targets presents exciting opportunities for advancing precision medicine in cervical cancer. By harnessing these insights, clinicians can optimize treatment selection, enhance patient outcomes, and ultimately transform the management of this devastating disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Neoplasias do Colo do Útero / Medicina de Precisão / Terapia de Alvo Molecular Limite: Female / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Biomarcadores Tumorais / Neoplasias do Colo do Útero / Medicina de Precisão / Terapia de Alvo Molecular Limite: Female / Humans Idioma: En Revista: Biochim Biophys Acta Rev Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Índia