Comparison of growth factor levels in injectable platelet-rich fibrin obtained from healthy individuals and patients with chronic periodontitis: a pilot study.
BMC Oral Health
; 24(1): 527, 2024 May 03.
Article
em En
| MEDLINE
| ID: mdl-38702671
ABSTRACT
BACKGROUND:
This study aimed to assess and compare the concentrations of growth factors, white blood cells (WBCs), and platelets in injectable platelet-rich fibrin (i-PRF) derived from people with healthy periodontal conditions and those with chronic periodontitis.METHODS:
Venous blood samples were obtained from 30 patients diagnosed with chronic periodontitis (test group) and 30 participants with healthy periodontal conditions (control group). The i-PRF was then acquired from centrifuged blood. The growth factors (VEGF, IGF-1, TGF-ß1, PDGF-BB and EGF) released from the i-PRF samples were compared between groups with ELISA testing. The amounts of WBCs and platelets were also compared.RESULTS:
No significant differences in the concentrations of growth factors were found between the groups (the mean values for the control and test groups were, respectively IGF 38.82, 42.46; PDGF 414.25, 466.28; VEGF 375.69, 412.18; TGF-ß1 21.50, 26.21; EGF 138.62, 154.82). The test group exhibited a significantly higher WBC count than the control group (8.80 vs. 6.60, respectively). However, the platelet count did not show a statistically significant difference between the groups (control group 242.0 vs. test group 262.50). No significant correlation was observed between WBC count and growth factor level in either group.CONCLUSIONS:
The growth factor levels in i-PRFs did not exhibit significant difference between the two groups. This suggests that the levels of these growth factors may be unaffected by the periodontal disease.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fator de Crescimento Insulin-Like I
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Peptídeos e Proteínas de Sinalização Intercelular
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Fator A de Crescimento do Endotélio Vascular
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Fator de Crescimento Transformador beta1
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Periodontite Crônica
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Fibrina Rica em Plaquetas
Limite:
Adult
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Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
BMC Oral Health
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Turquia