Targeting metabolic circuitry to supercharge CD8<sup>+</sup> T cell antitumor responses.

Cai, Qiang; Tian, Yihao; Shubhra, Quazi T H

Targeting metabolic circuitry to supercharge CD8⁺ T cell antitumor responses.

Cai, Qiang; Tian, Yihao; Shubhra, Quazi T H.

Afiliação

Cai Q; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China. Electronic address: cqno@sina.com.
Tian Y; Department of Human Anatomy and Histology and Embryology, School of Basic Medical Sciences, Wuhan University, Wuhan, China.
Shubhra QTH; Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan 430060, China; Institute of Chemistry, University of Silesia in Katowice, Szkolna 9, 40-003 Katowice, Poland. Electronic address: shubhro.du@gmail.com.

Cell Metab ; 36(5): 884-886, 2024 May 07.

Article em En | MEDLINE | ID: mdl-38718753

ABSTRACT

ABSTRACT

Tumors compromise T cell functionality through various mechanisms, including the induction of a nutrient-scarce microenvironment, leading to lipid accumulation and metabolic reprogramming. Hunt et al. elucidate acetyl-CoA carboxylase's crucial role in regulating lipid metabolism in CD8+ T cells, uncovering a novel metabolic strategy to potentiate antitumor immune responses.

Assuntos

Acetil-CoA Carboxilase; Linfócitos T CD8-Positivos; Linfócitos T CD8-Positivos/metabolismo; Linfócitos T CD8-Positivos/imunologia; Humanos; Acetil-CoA Carboxilase/metabolismo; Animais; Neoplasias/imunologia; Neoplasias/metabolismo; Metabolismo dos Lipídeos; Microambiente Tumoral/imunologia

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Acetil-CoA Carboxilase / Linfócitos T CD8-Positivos Limite: Animals / Humans Idioma: En Revista: Cell Metab Assunto da revista: METABOLISMO Ano de publicação: 2024 Tipo de documento: Article

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