Spaced conditioned stimulus presentation facilitates the extinction of strong fear memory in mice.
Biochem Biophys Res Commun
; 718: 150071, 2024 Jul 23.
Article
em En
| MEDLINE
| ID: mdl-38735136
ABSTRACT
Inducing fear memory extinction by re-presenting a conditioned stimulus (CS) is the foundation of exposure therapy for post-traumatic stress disorder (PTSD). Investigating differences in the ability of different CS presentation patterns to induce extinction learning is crucial for improving this type of therapy. Using a trace fear conditioning paradigm in mice, we demonstrate that spaced presentation of the CS facilitated the extinction of a strong fear memory to a greater extent than continuous CS presentation. These results lay the groundwork for developing more effective exposure therapy techniques for PTSD.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Condicionamento Clássico
/
Extinção Psicológica
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Medo
/
Memória
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Camundongos Endogâmicos C57BL
Limite:
Animals
Idioma:
En
Revista:
Biochem Biophys Res Commun
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão