Clinical and molecular correlates of the Index of Severity for Eosinophilic Esophagitis.
J Allergy Clin Immunol
; 154(2): 375-386.e4, 2024 Aug.
Article
em En
| MEDLINE
| ID: mdl-38750825
ABSTRACT
BACKGROUND:
The Index of Severity for Eosinophilic Esophagitis (I-SEE) is a new expert-defined clinical tool that classifies disease severity of eosinophilic esophagitis (EoE).OBJECTIVE:
We aimed to determine whether I-SEE is associated with patient characteristics, molecular features of EoE, or both.METHODS:
We analyzed a prospective cohort of patients with EoE from the Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). Associations between I-SEE and clinical and molecular features (assessed by an EoE diagnostic panel [EDP]) were assessed.RESULTS:
In 318 patients with chronic EoE (209 adults, 109 children), median total I-SEE score was 7.0, with a higher symptoms and complications score in children than adults (4.0 vs 1.0; P < .001) and higher inflammatory and fibrostenotic features scores in adults than children (3.0 vs 1.0 and 3.0 vs 0, respectively; both P < .001). Total I-SEE score had a bimodal distribution with the inactive to moderate categories and severe category. EDP score correlated with total I-SEE score (r = -0.352, P < .001) and both inflammatory and fibrostenotic features scores (r = -0.665, P < .001; r = -0.446, P < .001, respectively), but not with symptoms and complications scores (r = 0.047, P = .408). Molecular severity increased from inactive to mild and moderate, but not severe, categories. Longitudinal changes of modified I-SEE scores and inflammatory and fibrostenotic features scores reflected histologic and molecular activity.CONCLUSIONS:
I-SEE score is associated with select clinical features across severity categories and with EoE molecular features for nonsevere categories, warranting further validation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Índice de Gravidade de Doença
/
Esofagite Eosinofílica
Limite:
Adolescent
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Adult
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Child
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Child, preschool
/
Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Allergy Clin Immunol
/
J. allergy clin. immunol
/
Journal of allergy and clinical immunology
Ano de publicação:
2024
Tipo de documento:
Article