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Lipid Identification of Biomarkers in Esophageal Squamous Cell Carcinoma by Lipidomic Analysis.
Si, Tingwei; Liu, Daoqin; Li, Lei; Xu, Zichen; Jiang, Luqing; Zhai, Ying; Wu, Qiwen.
Afiliação
  • Si T; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Liu D; Department of Kidney Medicine, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Li L; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Xu Z; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Jiang L; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Zhai Y; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
  • Wu Q; Clinical Laboratory, The First Affiliated Hospital of Wannan Medical College, Wuhu, China.
Nutr Cancer ; 76(7): 608-618, 2024.
Article em En | MEDLINE | ID: mdl-38753560
ABSTRACT
Lipids participate in many important biological functions through energy storage, membrane structure stabilization, signal transduction, and molecular recognition. Previous studies have shown that patients with esophageal squamous cell carcinoma (ESCC) have abnormal lipid metabolism. However, studies characterizing lipid metabolism in ESCC patients through lipidomics are limited. Plasma lipid profiles of 65 ESCC patients and 42 healthy controls (HC) were characterized by lipidomics-based ultraperformance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Single-factor and multi-factor statistical analysis were used to screen the differences in blood lipids between groups, and combined with component ratio analysis and receiver operating characteristic (ROC) curve diagnostic efficiency assessment, to reveal the potential mechanisms and biomarkers of ESCC. There were significant differences in lipid profiles between the ESCC and HC groups. Thirty-six differential lipids (11 up-regulated and 25 down-regulated) were selected based on the criteria of p < .05 and fold change > 1.3 or < 0.77. Glycerophospholipids were the major differential lipids, suggesting that these lipid metabolic pathways exhibit a significant imbalance that may contribute to the development of esophageal squamous cell carcinoma. Among them, the seven candidate biomarkers for esophageal squamous cell carcinoma with the highest diagnostic value are three phosphatidylserine (PS), three fatty acids (FA) and one phosphatidylcholine (PC).
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Biomarcadores Tumorais / Carcinoma de Células Escamosas do Esôfago / Lipidômica Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Biomarcadores Tumorais / Carcinoma de Células Escamosas do Esôfago / Lipidômica Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Nutr Cancer Ano de publicação: 2024 Tipo de documento: Article País de afiliação: China