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Fatty Acids and Their Lipogenic Enzymes in Anorexia Nervosa Clinical Subtypes.
Nguyen, Nhien; Woodside, D Blake; Lam, Eileen; Quehenberger, Oswald; German, J Bruce; Shih, Pei-An Betty.
Afiliação
  • Nguyen N; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA.
  • Woodside DB; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada.
  • Lam E; Centre for Mental Health, University Health Network, Toronto, ON M5G 2C4, Canada.
  • Quehenberger O; Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093, USA.
  • German JB; Department of Food Science & Technology, University of California, Davis, Davis, CA 95616, USA.
  • Shih PB; Department of Psychiatry, University of California, San Diego, La Jolla, CA 92037, USA.
Int J Mol Sci ; 25(10)2024 May 18.
Article em En | MEDLINE | ID: mdl-38791555
ABSTRACT
Disordered eating behavior differs between the restricting subtype (AN-R) and the binging and purging subtype (AN-BP) of anorexia nervosa (AN). Yet, little is known about how these differences impact fatty acid (FA) dysregulation in AN. To address this question, we analyzed 26 FAs and 7 FA lipogenic enzymes (4 desaturases and 3 elongases) in 96 women 25 AN-R, 25 AN-BP, and 46 healthy control women. Our goal was to assess subtype-specific patterns. Lauric acid was significantly higher in AN-BP than in AN-R at the fasting timepoint (p = 0.038) and displayed significantly different postprandial changes 2 h after eating. AN-R displayed significantly higher levels of n-3 alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid (EPA), docosapentaenoic acid, and n-6 linoleic acid and gamma-linolenic acid compared to controls. AN-BP showed elevated EPA and saturated lauric acid compared to controls. Higher EPA was associated with elevated anxiety in AN-R (p = 0.035) but was linked to lower anxiety in AN-BP (p = 0.043). These findings suggest distinct disordered eating behaviors in AN subtypes contribute to lipid dysregulation and eating disorder comorbidities. A personalized dietary intervention may improve lipid dysregulation and enhance treatment effectiveness for AN.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anorexia Nervosa / Ácidos Graxos Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Anorexia Nervosa / Ácidos Graxos Limite: Adolescent / Adult / Female / Humans Idioma: En Revista: Int J Mol Sci Ano de publicação: 2024 Tipo de documento: Article País de afiliação: Estados Unidos