An easy assay to detect autoantibodies neutralizing cytokines in subjects with critical infections.
J Immunol Methods
; 530: 113696, 2024 Jul.
Article
em En
| MEDLINE
| ID: mdl-38797274
ABSTRACT
Autoantibodies against type I interferon (IFN) are associated with a worse outcome in COVID-19. The measurement of cytokine-neutralizing autoantibodies has been limited, hindering understanding of their role in clinical practice. We showed that an easy and reliable assay can be reproduced and validated to measure the neutralizing potency of autoantibodies directed to type I or type II IFN. Identifying of anti-cytokine autoantibodies might reflect on early treatments for subsequent infections, such as with antivirals or virus-neutralizing monoclonal antibodies.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
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Anticorpos Neutralizantes
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SARS-CoV-2
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COVID-19
Limite:
Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Immunol Methods
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Itália