Platelets, inflammation, and purinergic receptors in chronic kidney disease.
Kidney Int
; 106(3): 392-399, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38821448
ABSTRACT
Platelets are anucleated cells that circulate in the bloodstream. Historically, platelets were thought to perform a singular function-stop bleeding via clotting. Although platelets do play a key role in hemostasis and thrombosis, recent studies indicate that platelets also modulate inflammation, and this platelet-induced inflammation contributes to the pathophysiology of various diseases such as atherosclerosis and diabetes mellitus. Thus, in recent years, our understanding of platelet function has broadened. In this review, we revisit the classic role of platelets in hemostasis and thrombosis and describe the newly recognized function of platelets in modulating inflammation. We cover the potential use of purinergic receptor antagonists to prevent platelet-modulated inflammation, particularly in patients with chronic kidney disease, and finally, we define key questions that must be addressed to understand how platelet-modulated inflammation contributes to the pathophysiology of chronic kidney disease.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Plaquetas
/
Receptores Purinérgicos
/
Insuficiência Renal Crônica
/
Inflamação
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Kidney Int
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos