Blastomere size in the human 2-cell embryo predicts the division order that leads to imbalanced lineage contribution to the future body.
MicroPubl Biol
; 20242024.
Article
em En
| MEDLINE
| ID: mdl-38841597
ABSTRACT
Retrospective tracing of somatic mutations predicted that most cells in the human body could be traced back to a single cell of the 2-cell stage embryo. Accordingly, a recent prospective study of the developmental trajectory of blastomeres in human embryos confirmed that progeny of the first 2-cell stage blastomere to divide generates more epiblast cells (future body). How the 2-cell blastomeres differ is unknown. Here, we show that 2-cell stage blastomeres in human embryos are asymmetric; they differ in size and the bigger blastomere divides first to 4-cell stage. We propose that this asymmetry might originate differences in cell fate.
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1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
MicroPubl Biol
Ano de publicação:
2024
Tipo de documento:
Article