The drug titration paradox: a control engineering perspective.
Curr Opin Anaesthesiol
; 37(4): 362-370, 2024 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-38841991
ABSTRACT
PURPOSE OF REVIEW The drug titration paradox describes that, from a population standpoint, drug doses appear to have a negative correlation with its clinical effect. This paradox is a relatively modern discovery in anesthetic pharmacology derived from large clinical data sets. This review will interpret the paradox using a control engineering perspective. RECENT FINDINGS:
Drug titration is a challenging endeavor, and the medication delivery systems used in everyday clinical practice, including infusion pumps and vaporizers, typically do not allow for rapid or robust titration of medication being delivered. In addition, clinicians may be reluctant to deviate from a predetermined plan or may be content to manage patients within fixed goal boundaries.SUMMARY:
This drug titration paradox describes the constraints of how the average clinician will dose a patient with an unknown clinical response. While our understanding of the paradox is still in its infancy, it remains unclear how alternative dosing schemes, such as through automation, may exceed the boundaries of the paradox and potentially affect its conclusions.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anestésicos
Limite:
Humans
Idioma:
En
Revista:
Curr Opin Anaesthesiol
/
Curr. opin. anaesthesiol
/
Current opinion in anaesthesiology
Assunto da revista:
ANESTESIOLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Estados Unidos