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Neglected Mycobacterium Avium Complex Infection in a Patient with Prolonged Pneumonia.
Clin Lab ; 70(6)2024 Jun 01.
Article em En | MEDLINE | ID: mdl-38868891
ABSTRACT

BACKGROUND:

Non-tuberculous mycobacterial pulmonary infections (NTM-PD) are becoming increasingly common in clinical practice, and early detection and accurate determination of the infecting pathogen is crucial for subsequent treatment. We report a case of NTM-PD in a healthy middle-aged female with Mycobacterium tuberculosis complex group (MAC) infection confirmed by mNGS examination.

METHODS:

Appropriate laboratory tests, chest CT scan, bronchoscopic alveolar lavage fluid (BALF) examination, and macrogenomic next-generation sequencing (mNGS) were performed to establish the diagnosis.

RESULTS:

Chest CT showed multiple inflammatory lesions in the right middle lobe, and BALF sent for mNGS finally confirmed the diagnosis of MAC infection. After symptomatic treatment with azithromycin combined with ethambutol and rifampicin, the patient improved and was discharged from the hospital.

CONCLUSIONS:

In patients with pulmonary infections, pathogens should be clarified early to determine the diagnosis. mNGS of BALF samples have high specificity in detecting pathogens of infectious diseases, especially complex mixed infectious disease pathogens.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido da Lavagem Broncoalveolar / Complexo Mycobacterium avium / Infecção por Mycobacterium avium-intracellulare Limite: Female / Humans / Middle aged Idioma: En Revista: Clin Lab Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Líquido da Lavagem Broncoalveolar / Complexo Mycobacterium avium / Infecção por Mycobacterium avium-intracellulare Limite: Female / Humans / Middle aged Idioma: En Revista: Clin Lab Assunto da revista: TECNICAS E PROCEDIMENTOS DE LABORATORIO Ano de publicação: 2024 Tipo de documento: Article