Brain carbon monoxide can suppress the rat micturition reflex through brain γ-aminobutyric acid receptors.
Int J Urol
; 31(9): 1052-1060, 2024 Sep.
Article
em En
| MEDLINE
| ID: mdl-38884570
ABSTRACT
OBJECTIVES:
To investigate roles of brain carbon monoxide (CO), an endogenous gasotransmitter, in regulation of the rat micturition reflex.METHODS:
In urethane-anesthetized (0.8 g/kg, ip) male rats, evaluation of urodynamic parameters was started 1 h before intracerebroventricular administration of CORM-3 (CO donor) or ZnPP (non-selective inhibitor of heme oxygenase, a CO producing enzyme) and continued for 2 h after the administration. We also investigated effects of centrally pretreated SR95531 (GABAA receptor antagonist) or SCH50911 (GABAB receptor antagonist) on the CORM-3-induced response.RESULTS:
CORM-3 significantly prolonged intercontraction intervals (ICIs) without changing maximal voiding pressure (MVP), while ZnPP significantly shortened ICI and reduced single-voided volume and bladder capacity without affecting MVP, post-voided residual volume, or voiding efficiency. The ZnPP-induced ICI shortening was reversed by CORM-3. The CORM-3-induced ICI prolongation was significantly attenuated by centrally pretreated SR95531 or SCH50911, respectively.CONCLUSIONS:
Brain CO can suppress the rat micturition reflex through brain γ-aminobutyric acid (GABA) receptors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Micção
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Bexiga Urinária
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Encéfalo
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Monóxido de Carbono
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Ratos Sprague-Dawley
Limite:
Animals
Idioma:
En
Revista:
Int J Urol
Assunto da revista:
UROLOGIA
Ano de publicação:
2024
Tipo de documento:
Article
País de afiliação:
Japão